A silk sericin/silicone nerve guidance conduit promotes regeneration of a transected sciatic nerve

Advanced Healthcare Materials
Hongjian XieLin Wang

Abstract

Peripheral nerve gap defects lead to significant loss of sensory or motor function. Tissue engineering has become an important alternative to nerve repair. Sericin, a major component of silk, is a natural protein whose value in tissue engineering has just begun to be explored. Here, the first time use of sericin in vivo is reported as a long-term implant for peripheral nerve regeneration. A sericin nerve guidance conduit is designed and fabricated. This conduit is highly porous with mechanical strength matching peripheral nerve tissue. It supports Schwann cell proliferation and is capable of up-regulating the transcription of glial cell derived neurotrophic factor and nerve growth factor in Schwann cells. The sericin conduit wrapped with a silicone conduit (sericin/silicone double conduits) is used for bridging repair of a 5 mm gap in a rat sciatic nerve transection model. The sericin/silicone double conduits achieve functional recovery comparable to that of autologous nerve grafting as evidenced by drastically improved nerve function and morphology. Importantly, this improvement is mainly attributed to the sericin conduit as the silicone conduit alone only produces marginal functional recovery. This sericin/silicone-double-con...Continue Reading

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Citations

Apr 13, 2017·Scientific Reports·Jie TaoMaling Gou
Sep 13, 2017·Macromolecular Bioscience·Vaibhav SharmaElena García-Gareta
Sep 22, 2018·Advanced Healthcare Materials·Chris HollandF Philipp Seib
Jan 7, 2020·Biomaterials Science·Ana Catarina PinhoJorge Fernando Jordão Coelho
Jul 17, 2020·Microscopy Research and Technique·Lu MaMingying Yang
Sep 18, 2020·Advanced Healthcare Materials·Yu SongLin Wang
Apr 24, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lu MaChuanbin Mao
Apr 28, 2019·Journal of Biomaterials Applications·Dihan SuLibo Jiang
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Yuqing NiuMing Fu
Mar 18, 2021·ACS Biomaterials Science & Engineering·Sara Baptista-SilvaAna Leite Oliveira
May 27, 2021·Advanced Healthcare Materials·Qingqing LuDavid L Kaplan

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