PMID: 9420281Jan 7, 1998Paper

A similar pattern of interaction for different antibodies with a major antigenic site of foot-and-mouth disease virus: implications for intratypic antigenic variation

Journal of Virology
N VerdaguerI Fita

Abstract

The three-dimensional structures of the Fab fragment of a neutralizing antibody raised against a foot-and-mouth disease virus (FMDV) of serotype C1, alone and complexed to an antigenic peptide representing the major antigenic site A (G-H loop of VP1), have been determined. As previously seen in a complex of the same antigen with another antibody which recognizes a different epitope within antigenic site A, the receptor recognition motif Arg-Gly-Asp and some residues from an adjacent helix participate directly in the interaction with the complementarity-determining regions of the antibody. Remarkably, the structures of the two antibodies become more similar upon binding the peptide, and both undergo considerable induced fit to accommodate the peptide with a similar array of interactions. Furthermore, the pattern of reactivities of five additional antibodies with versions of the antigenic peptide bearing amino acid replacements suggests a similar pattern of interaction of antibodies raised against widely different antigens of serotype C. The results reinforce the occurrence of a defined antigenic structure at this mobile, exposed antigenic site and imply that intratypic antigenic variation of FMDV of serotype C is due to subtle s...Continue Reading

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Citations

Aug 12, 2005·Journal of Molecular Recognition : JMR·Vladimir N UverskyA Keith Dunker
Jan 25, 2007·The Journal of Biological Chemistry·Danielle DiCaraJohn F Marshall
Oct 29, 2003·Journal of Virology·Lakshmanan GovindasamyMavis Agbandje-McKenna
Apr 25, 2008·Current Protocols in Immunology·David Andreu, Paula Gomes
Jun 13, 2012·Microbiology and Molecular Biology Reviews : MMBR·Esteban DomingoCelia Perales
Nov 14, 2014·PloS One·Claudia SkamelAlain Bopda Waffo
Mar 23, 2000·Journal of Virology·C M Ruiz-JaraboE Domingo
Apr 23, 2002·The Journal of Peptide Research : Official Journal of the American Peptide Society·P GomesD Andreu
Apr 9, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·M L ValeroD Andreu
Feb 14, 2006·Proteins·Christos TzitzilonisJeremy P Derrick
Jul 11, 1998·Journal of Virology·E BaranowskiE Domingo
Jul 11, 2001·Biochemical and Biophysical Research Communications·P AlcaláA Villaverde
Sep 2, 1999·Biochemical and Biophysical Research Communications·E RamírezA Villaverde
Jan 12, 2002·Journal of Molecular Biology·Carmen M Ruíz-JaraboEsteban Domingo
Jan 16, 2003·Virus Research·Peter W MasonBarry Baxt

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