A simple and early prognostic index for acute renal failure patients requiring renal replacement therapy

Artificial Organs
S YuasaH Matsuo

Abstract

Recent advances in technology have not substantially changed the high mortality rate associated with acute renal failure (ARF). To obtain a simple, valid prognostic index, we retrospectively evaluated the relative importance of demographic data, causes (acute insults) of renal failure, and comorbid clinical conditions for the outcome in 102 ARF patients who received renal replacement therapy with an overall mortality rate of 65% (66 of 102). There were no significant differences between survivors and nonsurvivors in age and gender. Mortality according to acute insults was similar to that of the whole population studied. Of the 10 clinical conditions at the time of the first renal replacement therapy, mechanical ventilation (p = 0.0002), cardiac failure (p = 0.0006), hepatic failure (p = 0.003), central nervous system dysfunction (p = 0.005), and oliguria (p = 0.04) were found to be significantly related to mortality by univariate analysis. Furthermore, multivariate analysis demonstrated that only mechanical ventilation, cardiac failure, and hepatic failure were significant risk factors. Survival was directly related to the number of significant variables in univariate analysis: zero, 89% (8 of 9); one, 62% (21 of 34); two, 19% ...Continue Reading

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Citations

Dec 4, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nilzete BresolinFrancisca Ligia Carvalho
Jan 29, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Won Kyoung JhangSeong Jong Park
Feb 6, 2004·Best Practice & Research. Clinical Anaesthesiology·Neesh Pannu, Ravindra L Mehta
Apr 16, 2003·Scandinavian Journal of Infectious Diseases·Kenan KevenEkrem Erek
Mar 6, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Neesh Pannu, Ravindra L Mehta
Dec 2, 2010·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hideo YasudaUNKNOWN Shizuoka Kidney Disease Study Group

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