PMID: 6169765Jan 1, 1981Paper

A simple and effective method to assess murine delayed type hypersensitivity to proteins

Journal of Immunological Methods
R G Titus, J M Chiller

Abstract

Mice sensitized with various protein antigens emulsified in complete Freund's adjuvant by a subcutaneous injection at the base of the tail exhibited both immediate and delayed type hypersensitivities 7-8 days following sensitization. Hypersensitivity was assessed by the degree of footpad swelling elicited by challenge with a heat-aggregated form of the antigen. The swelling response was specific for the antigen used for sensitization and often resulted in a near doubling of footpad thickness. Histological examination is conjunction with studies having passive transfer of serum and adoptive transfer of either T cell-enriched or T cell-depleted preparations indicated that whereas the immediate swelling response was achieved with serum, the delayed swelling response was mediated by T lymphocytes. Adoptive transfer of specific delayed type hypersensitivity was also accomplished with small numbers of lymph node T cells obtained following in vitro enrichment and propagation.

References

Sep 1, 1979·European Journal of Immunology·A A AugustinH Cosenza
Dec 1, 1979·The Journal of Experimental Medicine·J Watson
Jun 1, 1975·Journal of Immunological Methods·W F Davidson, C R Parish
Jul 1, 1976·The Journal of Experimental Medicine·M A VadasA M Whitelaw
Mar 1, 1972·Antimicrobial Agents and Chemotherapy·J L BruschL Weinstein
Aug 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·T ISHIZAKA, K ISHIZAKA

❮ Previous
Next ❯

Citations

Jan 6, 1999·Archives of Pharmacal Research·E Y MoonD K Lee
May 25, 1984·Journal of Immunological Methods·G M HenningsenC A Osborne
Mar 1, 1991·Immunology Letters·A M Mowat, A M Donachie
Jul 26, 2003·Immunology Letters·Eleni Gonçalves BragaIeda Maria Longo-Maugéri
Sep 2, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·T NakanishiT Mayumi
Jan 16, 2002·International Immunopharmacology·Joung-Hoon Kim, Joung-Suk Park
Jul 4, 2002·International Immunopharmacology·Joung-Hoon KimJoung-Suk Park
Mar 1, 1993·The Veterinary Quarterly·P JolingA M Henken
Jan 1, 1997·Mediators of Inflammation·S FacinconeM Mariano
Mar 8, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Elisabete Regis CarneiroVera Lucia Flor Silveira
Nov 6, 2002·Journal of Periodontology·Wihaskoro SosrosenoGregory J Seymour
Mar 4, 2011·International Journal of Hygiene and Environmental Health·Qing ChenQingbin Zhang
Nov 6, 2009·Journal of Ethnopharmacology·Tulika Mishra, Aruna Bhatia
Apr 19, 2006·Phytotherapy Research : PTR·Sergey V PopovYury S Ovodov
Dec 24, 2005·Phytotherapy Research : PTR·S V PopovR G Ovodova
May 1, 1986·Cellular Immunology·T L McCurleyD G Colley
Mar 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Bianca HanbeukersLiesbeth Boersma
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S L LimaC M Gontijo
Mar 28, 2006·Journal of Photochemistry and Photobiology. B, Biology·Scott N ByrneGary M Halliday

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.