A simple and novel way of maintaining constant wall temperature in microdevices

Scientific Reports
V S DuryodhanAmit Agrawal

Abstract

Constant wall temperature /homogeneity in wall temperature is the need of various lab-on-chip devices employed in biological and chemical investigations. However method to maintain this condition does not seem to be available. In this work, a novel and simple way of maintaining constant wall temperature is proposed. A diverging microchannel along with conjugate effects is utilized towards this end. Both measurements and three dimensional numerical simulations are undertaken to prove the design. The investigation has been carried out over a large parameter range (divergence angle: 1-8°; length: 10-30 mm; depth: 86-200 μm; solid-to-fluid thickness ratio: 1.5-4.0, and solid-to-fluid thermal conductivity ratio: 27-646) and input conditions (mass flow rate: 4.17 × 10(-5) -9.17 × 10(-5) kg/s, heat flux: 2.4-9.6 W/cm(2)) which helped in establishing the finding. It is observed that a nearly constant wall temperature condition can be achieved over a large parameter range investigated. A model to arrive at the design parameter values is also proposed. The method is further demonstrated for series of microchannels where we successfully maintain each station at different temperature within ± 1 °C. The finding is therefore significant and ...Continue Reading

References

Jul 25, 2000·Analytical Chemistry·J KhandurinaJ M Ramsey
Mar 26, 2003·Journal of Microbiological Methods·Sou-ichi Makino, Hyeng-il Cheun
Dec 8, 2004·Biotechnology and Bioengineering·Paul J HungLuke P Lee
Oct 30, 2012·Biomedical Microdevices·Yuan WanSamir M Iqbal
Jan 1, 2013·Diagnostics·Vincent MirallesMarie-Caroline Jullien

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Citations

Jun 10, 2016·Scientific Reports·Siddhartha TripathiSuhas S Joshi

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Methods Mentioned

BETA
PCR
electrophoresis
reverse transcription RT-PCR
chip

Software Mentioned

Graphtec Midi Logger
Fluent

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