A Simple and Practical Index to Measure Dementia-Related Quality of Life

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Alexander M M AronsPaul F M Krabbe

Abstract

Research on new treatments for dementia is gaining pace worldwide in an effort to alleviate this growing health care problem. The optimal evaluation of such interventions, however, calls for a practical and credible patient-reported outcome measure. To describe the refinement of the Dementia Quality-of-life Instrument (DQI) and present its revised version. A prototype of the DQI was adapted to cover a broader range of health-related quality of life (HRQOL) and to improve consistency in the descriptions of its domains. A valuation study was then conducted to assign meaningful numbers to all DQI health states. Pairs of DQI states were presented to a sample of professionals working with people with dementia and a representative sample of the Dutch population. They had to repeatedly select the best DQI state, and their responses were statistically modeled to obtain values for each health state. In total, 207 professionals working with people with dementia and 631 members of the general population completed the paired comparison tasks. Statistically significant differences between the two samples were found for the domains of social functioning, mood, and memory. Severe problems with physical health and severe memory problems were d...Continue Reading

References

May 8, 1995·PharmacoEconomics·G W TorranceM Boyle
Mar 18, 2000·Health Economics·G A De WitF T De Charro
Jul 27, 2001·Medical Care·C Selai
Apr 10, 2002·Journal of Health Economics·John BrazierMark Deverill
Nov 15, 2003·Journal of Clinical Epidemiology·J AnkriF Blanchard
Aug 24, 2004·Health Economics·Richard HollandElizabeth Lenaghan
Mar 2, 2005·International Journal of Technology Assessment in Health Care·Cynthia P IglesiasUNKNOWN NEVALAT Project Group
Nov 30, 2006·International Journal of Geriatric Psychiatry·Carla J M Schölzel-DorenbosRose-Marie Dröes
Sep 7, 2007·Alzheimer Disease and Associated Disorders·Cathleen M ConnellSara J McLaughlin
May 8, 2008·American Journal of Alzheimer's Disease and Other Dementias·Tessa S Lundquist, Rebecca E Ready
Feb 20, 2010·Journal of the American Geriatrics Society·Carla J M Schölzel-DorenbosPaul F M Krabbe
May 17, 2011·Health and Quality of Life Outcomes·Paul Fm KrabbePiet Lcm van Riel
Mar 22, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Brendan MulhernSube Banerjee
May 17, 2012·BMJ : British Medical Journal·Els J MeeuwsenMarcel G M Olde Rikkert
Jun 2, 2012·Journal of Clinical Epidemiology·Alexander M M AronsMarcel G M Olde Rikkert
Aug 8, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Alexander M M AronsPaul F M Krabbe
Sep 27, 2012·Health and Quality of Life Outcomes·Carla J M Schölzel-DorenbosPaul F M Krabbe
Jan 23, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Brendan MulhernAki Tsuchiya
Feb 14, 2013·Expert Review of Pharmacoeconomics & Outcomes Research·Alexander M M Arons, Paul F M Krabbe

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Citations

Jan 27, 2017·Health and Quality of Life Outcomes·Kim-Huong NguyenTracy Comans
Oct 21, 2017·PharmacoEconomics·Donna RowenIsmail Azzabi Zouraq
Apr 22, 2020·PharmacoEconomics·Tracy A ComansBrendan Mulhern
Jul 15, 2020·International Journal of Geriatric Psychiatry·Elizabeth G Birkenhäger-GillesseSytse U Zuidema
Jun 26, 2018·Physical Therapy·Michiel F RenemanPaul F M Krabbe

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