A simple animal model of hyperammonemia

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
I AzorínS Grisolía

Abstract

Rats were fed a standard diet or the standard diet supplemented with ammonium acetate (20% w/w) for up to 100 days. The effect of the ingestion of the high-ammonium diet on some aspects of nitrogen metabolism in rats was studied. Ammonia levels in blood increased approximately 3-fold; in brain, liver and muscle the increases were 36, 34 and 50%, respectively. Urea levels in blood and urea excretion increased approximately 2-fold. There was no increase of carbamyl phosphate synthase. Liver glutamine synthase activity increased by 58% and glutamate dehydrogenase by 40%, whereas glutaminase was not affected. Glutamine content in brain was twice that of controls. This new animal model to study hyperammonemia offers several advantages over others: it is simpler, is bloodless, requires no animal manipulation and permits long-term studies.

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Citations

Dec 1, 1989·Neurochemical Research·M D MiñanaS Grisolía
Sep 1, 1993·Neurochemical Research·G BodegaB Fernández
Oct 31, 2012·Journal of Inherited Metabolic Disease·Olivier BraissantCristina Cudalbu
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Jan 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Slaven ErcegVicente Felipo
Mar 17, 2010·Molecular Genetics and Metabolism·Olivier Braissant
Jun 5, 1989·FEBS Letters·M D MiñanaS Grisolía
Sep 21, 2007·Brain Research Reviews·Laurène Cagnon, Olivier Braissant
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rodrigo JoverMiguel Pérez-Mateo
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Aug 18, 2004·Neurochemistry International·Regina RodrigoVicente Felipo
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Dec 31, 2005·Metabolic Brain Disease·Rodrigo JoverAntonio Compañ
Dec 28, 2017·Proceedings of the National Academy of Sciences of the United States of America·Leandro R SoriaNicola Brunetti-Pierri
Sep 1, 1990·Neurochemical Research·V FelipoS Grisolía

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