A simple approach for coupling liquid chromatography and electron ionization mass spectrometry

Journal of the American Society for Mass Spectrometry
A CappielloP Palma

Abstract

A miniaturized, aerosol based interface for directly coupling a liquid chromatograph with a mass spectrometer is presented. The interface is entirely within the electron ionization (EI) source of the mass spectrometer and no additional, external devices are needed. This simple and effective approach exploits micro-flow nebulization technology providing a new interface suitable for a variety of applications of environmental and biological interest. The new interface provides necessary linearity, ruggedness, sensitivity, and reproducibility of response for trace level analysis, and readily interpretable mass spectra for unambiguous identification of unknown compounds of small to medium molecular weight.

Citations

Oct 28, 2015·Journal of Mass Spectrometry : JMS·Boaz SeemannAviv Amirav
Mar 10, 2011·Mass Spectrometry Reviews·Achille CappielloHelga Trufelli
Sep 19, 2015·Journal of Chromatography. a·Carlos E D NazarioFernando M Lanças
Jul 19, 2002·Journal of Mass Spectrometry : JMS
Apr 22, 2004·European Journal of Mass Spectrometry·Gary J Van Berkel
Jul 12, 2007·Journal of Separation Science·Javier Hernández-BorgesSalvatore Fanali
Feb 13, 2020·Briefings in Bioinformatics·Zainab NoorAbidali Mohamedali
Feb 21, 2021·Journal of Chromatography. a·Francesca RiganoLuigi Mondello
Jun 25, 2009·Analytical Chemistry·Achille CappielloHelga Trufelli
May 30, 2021·Analytica Chimica Acta·Giorgio FamigliniAchille Cappiello
Jun 17, 2020·Journal of the American Society for Mass Spectrometry·Svetlana TsizinAviv Amirav
Mar 19, 2008·Analytical Chemistry·G FamigliniA Cappiello

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