A Simple Approach for Molecular Controlled Release based on Atomic Layer Deposition Hybridized Organic-Inorganic Layers

Scientific Reports
Christian BoehlerMaria Asplund

Abstract

On-demand release of bioactive substances with high spatial and temporal control offers ground-breaking possibilities in the field of life sciences. However, available strategies for developing such release systems lack the possibility of combining efficient control over release with adequate storage capability in a reasonably compact system. In this study we present a new approach to target this deficiency by the introduction of a hybrid material. This organic-inorganic material was fabricated by atomic layer deposition of ZnO into thin films of polyethylene glycol, forming the carrier matrix for the substance to be released. Sub-surface growth mechanisms during this process converted the liquid polymer into a solid, yet water-soluble, phase. This layer permits extended storage for various substances within a single film of only a few micrometers in thickness, and hence demands minimal space and complexity. Improved control over release of the model substance Fluorescein was achieved by coating the hybrid material with a conducting polymer film. Single dosage and repetitive dispensing from this system was demonstrated. Release was controlled by applying a bias potential of ± 0.5 V to the polymer film enabling or respectively s...Continue Reading

References

Dec 20, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Reecha WadhwaXinyan Tracy Cui
Jan 31, 2009·Biomaterials·Rachael T RichardsonStephen J O'Leary
Dec 1, 2009·Tissue Engineering. Part B, Reviews·Kyle D AllenLori A Setton
Dec 2, 2009·Chemical Reviews·Steven M George
Feb 10, 2010·Journal of Materials Science. Materials in Medicine·Lucas LeprinceSophie Demoustier-Champagne
Feb 18, 2010·Electrochemistry Communications·Xiliang Luo, Xinyan Tracy Cui
Feb 19, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Jesse S JurGregory N Parsons
Apr 3, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Darren SvirskisSanjay Garg
Sep 23, 2010·Advanced Materials·Zhipeng HuangUlrich Gösele
Jan 19, 2011·Nanotechnology·Sirinrath SirivisootThomas J Webster
Jun 18, 2011·Expert Opinion on Drug Delivery·Katharina Ladewig
Dec 14, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jesse B WolinskyMark W Grinstaff
Jan 17, 2014·ACS Nano·Cassandra L WeaverXinyan Tracy Cui
May 27, 2014·Frontiers in Neuroengineering·Maria AsplundThomas Stieglitz
Jun 11, 2014·Journal of Biomedical Materials Research. Part a·Christian Boehler, Maria Asplund

❮ Previous
Next ❯

Citations

Mar 10, 2018·Expert Opinion on Drug Delivery·Lorenzo VannozziLeonardo Ricotti
May 1, 2020·Nanotechnology·Karina AshurbekovaMato Knez
Mar 17, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Sabrina SchejaEvgeny Katz
Nov 13, 2019·ACS Applied Materials & Interfaces·Michael KasimatisFirat Güder

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning electron microscopy
fluorescence imaging
fluorescence microscopy
X-ray

Software Mentioned

MultiPak

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.