A simple approach to performing quantitative cancer risk assessment using published results from occupational epidemiology studies

The Science of the Total Environment
Edwin van Wijngaarden, I Hertz-Picciotto

Abstract

Quantitative risk assessment provides formalized scientific input for setting occupational and environmental standards for potentially toxic exposures. We describe the methods to perform quantitative cancer risk assessment based on published epidemiological literature using a hand calculator or spreadsheet. These methods are illustrated for some suspected or known human carcinogens, including perchloroethylene, formaldehyde, benzene and nickel. The approach to cancer risk assessment presented here may prove useful for those without access to original data from epidemiologic studies. The methods described should facilitate the use of published epidemiological data in the estimation of cancer risk in the general or working population.

References

Mar 1, 1988·Archives of Environmental Health·A H Smith
Apr 1, 1995·American Journal of Public Health·I Hertz-Picciotto
Feb 1, 1995·American Journal of Industrial Medicine·L StaynerS H Moolgavkar
Aug 1, 1993·Scandinavian Journal of Work, Environment & Health·I Hertz-Picciotto, A H Smith
Oct 1, 1996·Human & Experimental Toxicology·K S Crump
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May 16, 2000·Occupational and Environmental Medicine·T L VaughanM Berwick
Aug 26, 2003·Scandinavian Journal of Work, Environment & Health·Leslie StaynerIrva Hertz-Picciotto

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Citations

Nov 10, 2007·Current Oncology Reports·Constance M Johnson, Derek Smolenski
Feb 25, 2006·Regulatory Toxicology and Pharmacology : RTP·R Alexandra GoldbohmE Dinant Kroese
Dec 22, 2017·Risk Analysis : an Official Publication of the Society for Risk Analysis·Stacy Fiebelkorn, Clive Meredith
Mar 30, 2021·Journal of the Air & Waste Management Association·Scott M Bartell, Verónica M Vieira

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