Abstract
Due to its rapidly proliferating matrix keratinocytes, the hair follicle is highly sensitive to ionizing irradiation (IR)-induced skin damage and thus an instructive and clinically relevant model organ for investigating the effects of IR on rapidly dividing epithelial-mesenchymal interaction systems. Here, we have assessed the impact of IR on organ-cultured human scalp hair follicles. We show that IR significantly inhibits the proliferation and induces apoptosis of hair follicle matrix keratinocytes, disrupts normal hair follicle pigmentation, and upregulates a number of quantitative toxicity and viability markers (oxidative stress indicators, DNA oxidative damage, LDH release). This introduces human hair follicle organ culture as an excellent novel research tool for radiobiology and invites exploitation as a preclinical assay system for testing candidate radioprotectants.
References
Jul 1, 1981·The Journal of Investigative Dermatology·F D Malkinson, J T Keane
Dec 18, 1998·The Journal of Investigative Dermatology·D J TobinR Paus
Jan 12, 2001·Physiological Reviews·K S Stenn, R Paus
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James M MetzStephen M Hahn
Jun 29, 2005·The Journal of Investigative Dermatology·Sven HendrixRalf Paus
Dec 1, 2005·Life Sciences·Bahar BaltalarliGülçin Abban
Dec 22, 2006·Experimental Dermatology·Zhongfa LuRalf Paus
May 24, 2007·Experimental Dermatology·Annesofie FaurschouHans Christian Wulf
Aug 19, 2007·Experimental Dermatology·Markus WalzThomas Ruzicka
Sep 8, 2007·The American Journal of Pathology·Eniko BodóRalf Paus
Jan 29, 2008·Photochemistry and Photobiology·Frank R de Gruijl, Heggert Rebel
Aug 16, 2008·The Journal of Investigative Dermatology·Eniko BodóRalf Paus
Dec 25, 2008·Environmental and Molecular Mutagenesis·Yaroslav IlnytskyyOlga Kovalchuk
Jan 23, 2009·The Journal of Investigative Dermatology·Zhongfa LuRalf Paus
Feb 13, 2009·Current Biology : CB·Marlon R SchneiderRalf Paus
Jun 16, 2009·Cell·Ken InomataEmi K Nishimura
Citations
Nov 27, 2010·Pigment Cell & Melanoma Research·Ralf Paus
Nov 21, 2018·Experimental Dermatology·QingXiang GaoZhiCao Yue
Jan 16, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Burkhard PoeggelerRalf Paus
Dec 18, 2019·International Journal of Radiation Biology·Rita HargitaiKatalin Lumniczky
May 9, 2012·Archives of Dermatological Research·Konrad Kleszczyński, Tobias W Fischer
Apr 21, 2016·Experimental Dermatology·Talveen S PurbaRalf Paus
Aug 19, 2015·Experimental Dermatology·Ewan A LanganRalf Paus
Jun 12, 2021·The Journal of Investigative Dermatology·Stephan TiedeRalf Paus
Sep 4, 2021·Journal of Autoimmunity·Youhei UchidaRalf Paus
Sep 9, 2021·The British Journal of Dermatology·I PicciniM Bertolini