A Simple Hydraulic Analog Model of Oxidative Phosphorylation

Medicine and Science in Sports and Exercise
Wayne T WillisBrian Glancy

Abstract

Mitochondrial oxidative phosphorylation is the primary source of cellular energy transduction in mammals. This energy conversion involves dozens of enzymatic reactions, energetic intermediates, and the dynamic interactions among them. With the goal of providing greater insight into the complex thermodynamics and kinetics ("thermokinetics") of mitochondrial energy transduction, a simple hydraulic analog model of oxidative phosphorylation is presented. In the hydraulic model, water tanks represent the forward and back "pressures" exerted by thermodynamic driving forces: the matrix redox potential (ΔGredox), the electrochemical potential for protons across the mitochondrial inner membrane (ΔGH), and the free energy of adenosine 5'-triphosphate (ATP) (ΔGATP). Net water flow proceeds from tanks with higher water pressure to tanks with lower pressure through "enzyme pipes" whose diameters represent the conductances (effective activities) of the proteins that catalyze the energy transfer. These enzyme pipes include the reactions of dehydrogenase enzymes, the electron transport chain (ETC), and the combined action of ATP synthase plus the ATP-adenosine 5'-diphosphate exchanger that spans the inner membrane. In addition, reactive oxygen...Continue Reading

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Citations

May 12, 2017·Cold Spring Harbor Perspectives in Medicine·P Darrell Neufer
Sep 30, 2017·Frontiers in Physiology·T Bradley Willingham, Kevin K McCully
Nov 10, 2017·American Journal of Physiology. Renal Physiology·Danielle L KirkmanDavid G Edwards
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Jan 14, 2021·Trends in Ecology & Evolution·Rebecca E KochAntoine Stier
Jun 17, 2021·ELife·Margaret Am NelsonKelsey H Fisher-Wellman
Aug 31, 2021·The Journal of Biological Chemistry·Cameron A SchmidtP Darrell Neufer

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