A simple matter of life and death-the trials of postnatal Beta-cell mass regulation.

International Journal of Endocrinology
Elena TarabraMichael Khan

Abstract

Pancreatic beta-cells, which secrete the hormone insulin, are the key arbiters of glucose homeostasis. Defective beta-cell numbers and/or function underlie essentially all major forms of diabetes and must be restored if diabetes is to be cured. Thus, the identification of the molecular regulators of beta-cell mass and a better understanding of the processes of beta-cell differentiation and proliferation may provide further insight for the development of new therapeutic targets for diabetes. This review will focus on the principal hormones and nutrients, as well as downstream signalling pathways regulating beta-cell mass in the adult. Furthermore, we will also address more recently appreciated regulators of beta-cell mass, such as microRNAs.

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Citations

Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jeffery S TessemChristopher B Newgard
Jun 3, 2017·International Journal of Molecular Sciences·Ángeles OrtegaBernat Soria
Jun 7, 2014·Current Opinion in Pediatrics·Lynne L LevitskyDavid B Rhoads
Jul 24, 2012·The Tohoku Journal of Experimental Medicine·Xiao-ye HeRen-ming Hu
Feb 6, 2020·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·A Uyar, N T Abdulrahman
Jul 1, 2015·Journal of Microscopy and Ultrastructure·Eman Ali El-Kordy, Abdulrahman Mohammed Alshahrani
Feb 26, 2019·Oxidative Medicine and Cellular Longevity·Rongzi LiJeganathan Ramesh Babu

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Methods Mentioned

BETA
transgenic
nuclear translocation

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