A simple mechanistic terminology of psychoactive drugs: a proposal.

Naunyn-Schmiedeberg's Archives of Pharmacology
Roland Seifert, Bastian Schirmer

Abstract

Antidepressants, antiepileptics, mood stabilizers, and antipsychotics are extremely broadly used psychoactive drugs. These drug terms are universally used in the literature. However, the indications of these drugs have broadened substantially and overlap. The mismatch between drug classification and clinical uses causes a lot of confusion in communication and renders literature searches increasingly difficult. Therefore, we propose to drop the above terms altogether and replace them by simple mechanistic terms. Antidepressants are re-named as norepinephrine/serotonin (NE/5-HT) enhancers, antiepileptics comprising drugs with different mechanisms become neuronal inhibitors with pleiotropic effects (NIPEs), and antipsychotics become antagonists at multiple G protein-coupled receptors (mGPCR antagonists). Alkali metal ions, comprising lithium, are integrated into NIPEs. The terms "typical/first-generation/conventional" and "atypical/second-generation/non-conventional" antipsychotics should be dropped, because the original criterion for distinction, i.e., the presence and absence of extrapyramidal motor effects, respectively, is not valid anymore. The suggested changes in drug nomenclature have already been implemented into a recent...Continue Reading

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Citations

Sep 12, 2020·Expert Opinion on Drug Discovery·Piotr StępnickiAgnieszka A Kaczor
Jan 7, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Lenka RoubalováPetr Svoboda
Apr 26, 2021·Trends in Microbiology·Roland Seifert, Bastian Schirmer
Jun 24, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Roland Seifert, Bastian Schirmer
Oct 27, 2021·Physiological Reviews·Katrina F OstromRennolds S Ostrom

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