A simple method for assessing quinine pre-treatment in acute malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene
K SilamutN J White

Abstract

Administration of a loading dose of quinine in severe malaria may be dangerous if therapeutic blood concentrations are already present because of previous treatment. To assess the reliability of the history of pretreatment we conducted a prospective study of 379 adult patients with acute falciparum malaria admitted to a hospital in western Thailand. Admission plasma concentrations of quinine were measured by high performance liquid chromatography (HPLC), and compared with the patients' history of previous quinine treatment. The sensitivity of the history was 59% (95%) confidence interval [CI] 49-69%), the specificity was 79% (95% CI 74-84%), the positive predictive value was 53%, and the negative predictive value 82%. A rapid (10 min semi-quantitative estimate of plasma quinine concentrations, based on simple 'dipstick' method using a quinine-specific monoclonal antibody, proved considerably more sensitive and specific. The correlation between the dipstick estimate and the subsequent HPLC measurement of plasma quinine concentration was 0.85 (n = 404; P < 0.0001). In 404 admission samples, the negative predictive value of the dipstick estimate for plasma quinine concentrations > 1 microgram/mL was 100%. In Thailand the history o...Continue Reading

References

Jun 1, 1990·British Journal of Clinical Pharmacology·R J RocheN J White
Feb 16, 1985·Lancet·M E BolandJ A Henry
Jul 6, 1985·Lancet·S LooareesuwanD A Warrell
Jul 1, 1985·The American Journal of Tropical Medicine and Hygiene·K SilamutD A Warrell
Jul 6, 1985·British Medical Journal·E H DysonR Heyworth
Jan 1, 1983·The American Journal of Tropical Medicine and Hygiene·N J WhiteT Harinasuta
Jul 14, 1983·The New England Journal of Medicine·N J WhiteR C Turner
Jul 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·N J White

❮ Previous
Next ❯

Citations

Nov 8, 2006·European Journal of Clinical Pharmacology·Paul N NewtonNicholas J White
Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F SprangersH P Sauerwein
Nov 15, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·P N NewtonN J White
Jul 2, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mayfong MayxayNicholas J White
Nov 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·E DekkerH P Sauerwein
May 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·X T CaoN J White
Mar 24, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·W SupanaranondN J White
Feb 6, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Huynh van ThienH P Sauerwein
Dec 12, 2001·British Journal of Clinical Pharmacology·Y SuputtamongkolN J White
Jul 11, 1996·The New England Journal of Medicine·T H TranN J White
Jun 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul N NewtonNicholas J White
Mar 18, 2000·Antimicrobial Agents and Chemotherapy·P NewtonN White
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·Brian J AngusNicholas J White
Oct 25, 2003·Antimicrobial Agents and Chemotherapy·S PukrittayakameeN J White
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Kamolrat SilamutNicholas J White
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mayfong MayxayNicholas J White
Apr 4, 2008·Tropical Medicine & International Health : TM & IH·Wilco C W R ZijlmansHans P Sauerwein
Nov 4, 2016·Malaria Journal·Mauro Toledo Marrelli, Marco Brotto
Aug 1, 1997·The Journal of Clinical Endocrinology and Metabolism·E DekkerH P Sauerwein
May 29, 2004·American Journal of Physiology. Endocrinology and Metabolism·Huynh van ThienH P Sauerwein
Feb 24, 1998·Metabolism: Clinical and Experimental·E DekkerH P Sauerwein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie
H ReinauerF Susanto
European Journal of Clinical Pharmacology
S PukrittayakameeN J White
© 2021 Meta ULC. All rights reserved