A simple method to evaluate residual renal function by spot urinary cystatin C-to-creatinine ratio in peritoneal dialysis patients

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
Yoko Adachi, Akira Nishio

Abstract

Residual renal function (RRF) is a key element in the management of chronic peritoneal dialysis (PD) patients, and 24-hour creatinine clearance (24-h Ccr) and arithmetic mean of creatinine and urea nitrogen clearances [24-h (Ccr+Curea)/2] are still standard clinical techniques for the assessment of glomerular filtration rate (GFR) to represent RRF. However, it is sometimes difficult to monitor urine collection for 24 hours, especially in outpatients, and it requires serum sampling. Therefore, we devised a new and simple method to measure RRF in prevalent PD patients. Levels of urinary cystatin C (Cys-C) and creatinine in spot urine samples [24-h (Ccr+Curea)/2] were measured in 15 stable Japanese PD patients. Although no statistical correlation was seen between Cys-C and 24-h (Ccr+Curea)/2 values, a strong correlation was found between the spot urine Cys-C-to-creatinine ratio [U (Cys-C/Cr)] and 24-h (Ccr+Curea)/2. By simple linear regression analysis, the following regression equation was derived: y = 17.0 - 6.1x, where x = log 10,000(*)U (Cys-C/Cr) ratio and y = 24-h (Ccr+Curea)/2. Measurement of U (Cys-C/Cr) ratio does not require serum sampling or 24-hour urine collection but requires only a spot urine sample. We suggest that...Continue Reading

References

May 1, 1993·Journal of the American Society of Nephrology : JASN·A J King, A S Levey
Feb 19, 2002·Kidney International·Giovanni MontiniUNKNOWN Italian Registry of Pediatric Peritoneal Dialysis
Jul 24, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kazuo Uchida, Akiko Gotoh
Mar 12, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stanley HellersteinSylvia DiMaggio
Dec 21, 2004·Clinical Biochemistry·Guido FillerAnders Grubb

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Citations

Nov 12, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Su Jin KimKyung Hoon Paik
Oct 30, 2014·International Urology and Nephrology·Dominik SteublMarcel Roos
Jul 16, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Robert M LindsayGuido Filler

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Methods Mentioned

BETA
urine collection
urine collections

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