A simple model for potential use with a misclassified binary outcome in epidemiology

Journal of Epidemiology and Community Health
S W DuffyA Sadeghi-Hassanabadi

Abstract

Error in determination of disease outcome occurs in epidemiology, but such error is not usually corrected for in statistical analysis. A method of correction of risk estimates for misclassification of a binary disease outcome is developed here. The method is a simple, closed form correction to the logistic regression estimate. A closed form variance estimate is also developed. The method is illustrated in two studies, a cross sectional survey of cervicitis in Iran in 1996-97, as determined by inflammation on cervical smear specimens, and a case-cohort study of benign proliferative epithelial disease of the breast, in Canada 1980-88. The method provides corrected odds ratio estimates and corrects the spurious precision conferred by misclassification. The method is easy to apply and potentially useful, although potential failures of the assumptions involved should be borne in mind. It is necessary to give careful consideration to the plausibility or otherwise of the assumptions in the context of the individual study. Correction for misclassification of disease outcome may become more common with the development of readily applicable methods.

Citations

Mar 9, 2013·Public Health Nutrition·Monik JimenezThomas Dietrich
Oct 9, 2012·Diabetes Research and Clinical Practice·Monik JimenezKaumudi J Joshipura
Oct 8, 2011·Obesity·Monik JimenezKaumudi J Joshipura
Nov 6, 2007·American Journal of Obstetrics and Gynecology·Kathryn L TerryImmaculata De Vivo
Aug 15, 2014·Journal of Critical Care·Donald A RedelmeierDamon C Scales
Oct 6, 2007·Epidemiology·Kathryn L TerryStacey A Missmer

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