A simple modification of the water maze test to enhance daily detection of spatial memory in rats and mice

Journal of Neuroscience Methods
Se Hoon ChoiTimothy Schallert

Abstract

The water maze is one of the most frequently used tools in behavioral neuroscience. Many variations of the water maze task have been used; however, established water maze protocols have several disadvantages. Notably, these protocols demand considerable time to perform reference and probe tests separately. Here, we suggest a modified protocol, which is rapidly performed, is sensitive to cognitive deficits, and can assay reference as well as strategy-switching ability. The platform is relocated randomly within the target quadrant with each training trial. Because the rodents must spend more time searching within the target quadrant, every trial effectively becomes a probe trial. The rodents are then run in the switching strategy test, where the platform is randomly placed along the wall of the pool. The best new strategy would thus be to search along the walls of the pool systematically. The percent distance traveled and time spent near the wall is evaluated across trials, as is the distance traveled and time spent in the previously correct quadrant. In this way one can assess whether the rodent is continuing to search in the older platform location (i.e., displaying a strategy-switching problem) or whether it has successfully a...Continue Reading

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Citations

Sep 2, 2008·Psychopharmacology·Michael J SpinettaTimothy Schallert
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Timothy Schallert
Jul 21, 2010·Experimental & Translational Stroke Medicine·Krystal L SchaarSean I Savitz
Jul 28, 2009·Journal of Lipid Research·Dragana D BojanicPeter A Edwards
May 22, 2010·Journal of Neurosurgery·Ye XiongMichael Chopp
Feb 13, 2009·The Journal of Nutrition·Erik S CarlsonAnna Petryk
May 22, 2013·Neural Plasticity·Shaefali P RodgersJ Leigh Leasure
Mar 1, 2012·Brain Injury : [BI]·Hala DarwishBarbara Therrien
Oct 4, 2008·Behavioural Brain Research·Maria GulinelloDonald S Faber
Jul 21, 2007·Psychoneuroendocrinology·Muriel DarnaudéryStefania Maccari
Oct 12, 2012·Annals of the New York Academy of Sciences·Ye XiongMichael Chopp
Feb 24, 2015·Pharmacology, Biochemistry, and Behavior·Jafar Doost MohammadpourKambiz Rohampour
Jul 12, 2011·Neurochemistry International·Walaiporn TongjaroenbuangamPiyarat Govitrapong
Apr 5, 2011·Free Radical Biology & Medicine·Jia ShenQiang Xia
Jan 24, 2015·Journal of Neurosurgery·Yanlu ZhangYe Xiong
Oct 19, 2016·Journal of Neurotrauma·Stacy L SellDonald S Prough
Jun 17, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Quan JiangZhenggang Zhang
Feb 15, 2013·Toxicology and Industrial Health·Mansour A Al-HazmiAyat Os Montasser
Nov 11, 2017·Journal of Neurotrauma·Yanlu ZhangYe Xiong

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