A simple prediction score for estimating the risk of candidaemia caused by fluconazole non-susceptible strains

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
G CuervoCANDIPOP project and the validation cohort project

Abstract

We aimed to develop a simple prediction score to identify fluconazole non-susceptible (Flu-NS) candidaemia using simple clinical criteria. A derivation cohort was extracted from the CANDIPOP study, a prospective, multicentre, population-based surveillance programme on candidaemia conducted in 29 hospitals in Spain from April 2010 to May 2011. The score was validated with an external, multicentre cohort of adults with candidaemia in six tertiary hospitals in three countries. The prediction score was based on three variables selected by a logistic regression model together with the severity of disease. In total, 617 and 297 cases of candidaemia were included in the derivation and validation cohorts, respectively; of these, 134 (21.7%) and 57 (19.2%) were caused by Flu-NS strains. Factors independently associated with Flu-NS were transplant recipient status (adjusted odds ratio (AOR) 2.13; 95% CI 1.01-4.55; p 0.047), hospitalization in a unit with a high prevalence (≥15%) of Flu-NS strains (7.53; 4.68-12.10; p < 0.001), and previous azole therapy for at least 3 days (2.04; 1.16-3.62; p 0.014). The area under the receiver operating characteristics curve (AUC) was 0.76 (0.72-0.81), and using 2 points as the Flu-NS prediction score c...Continue Reading

References

Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Jul 16, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Juliette MorganSteven M Teutsch
Sep 29, 2006·Antimicrobial Agents and Chemotherapy·Cornelius J ClancyM Hong Nguyen
Jan 15, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·UNKNOWN Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility T
Jun 17, 2008·Critical Care Medicine·E Geoffrey PlayfordTania C Sorrell
Sep 17, 2008·Antimicrobial Agents and Chemotherapy·Guillermo Garcia-EffronDavid S Perlin
Sep 24, 2008·Antimicrobial Agents and Chemotherapy·Luis Ostrosky-ZeichnerThomas J Walsh
Feb 5, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN Infectious Diseases Society of America
Feb 18, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S J van HalUNKNOWN Australian Candidaemia Study
May 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L HornKaren M Webster
Aug 12, 2009·Archives of Internal Medicine·Mario TumbarelloMaurizio Sanguinetti
Mar 6, 2010·The Journal of Antimicrobial Chemotherapy·Monica A SlavinUNKNOWN Australian Candidemia Study, Australasian Society for Infectious Diseases
May 26, 2010·Antimicrobial Agents and Chemotherapy·José Garnacho-MonteroCarlos Ortiz-Leyba
Oct 29, 2010·Journal of Clinical Microbiology·Maiken Cavling ArendrupKjeld Truberg
May 9, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Maiken C ArendrupUNKNOWN EUCAST-AFST
May 12, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Anupama RaghuramChristine E Koval
Mar 26, 2013·PloS One·Marcio NucciUNKNOWN Latin American Invasive Mycosis Network
Apr 24, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C ArendrupH C Schønheyder
Jul 31, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M N GamaletsouN V Sipsas
Oct 16, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Puig-AsensioUNKNOWN REIPI
Dec 25, 2013·Antimicrobial Agents and Chemotherapy·Jesús GuineaUNKNOWN CANDIPOP Project, GEIH-GEMICOMED (SEIMC), and REIPI
Jun 1, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicholas D BeydaKevin W Garey

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Citations

Jan 27, 2016·Mycoses·Sarah Santos GonçalvesArnaldo Lopes Colombo
Jul 11, 2016·Revista iberoamericana de micología·Ana Isabel RenauMiguel Salavert
Nov 11, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S AriasF Zech
Mar 23, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Guillermo CuervoUNKNOWN for Grupo de Estudio de Micología Médica (GEMICOMED), Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica
Feb 7, 2018·Current Infectious Disease Reports·Ilan S Schwartz, Thomas F Patterson
Jun 22, 2019·The Journal of Antimicrobial Chemotherapy·Carolina Garcia-VidalOlivier Lortholary
Dec 11, 2019·The Journal of Antimicrobial Chemotherapy·Celia CardozoUNKNOWN GEMICOMED (SEIMC) and the Spanish CANDI-Bundle Group
Oct 7, 2020·The Pediatric Infectious Disease Journal·Watsamon JantarabenjakulThanyawee Puthanakit
Feb 18, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V Garcia-BustosJ Pemán

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