Apr 27, 2020

Computational investigation for modelling the protein-protein interaction of TasA(28-261)with TapA(33-253); a decisive process in biofilm formation by Bacillus subtilis

BioRxiv : the Preprint Server for Biology
N. VermaJanmejay Pandey

Abstract

Biofilms have significant role in microbial persistence, antibiotic resistance and chronic infections. Consequently, there is a pressing need for development of novel anti-biofilm strategies. One of the fundamental mechanisms involved in biofilm formation is protein-protein interactions of amyloid like proteins (ALPs) in extracellular matrix. Such interactions could be potential targets for development of novel anti-biofilm strategies. Therefore, assessing the structural features of these interactions could be of great scientific value. Characterization of biomolecular interaction with conventional structure biology tools including X- Ray diffraction and Nuclear Magnetic Resonance is technically challenging, expensive and time-consuming. In contrast, modelling such interactions is time-efficient, economical and might provide deeper understanding of structural basis of interactions. Therefore, during the present study, protein-protein interaction of TasA(28-261) with TapA(33-253), which is a decisive process for biofilm formation by Bacillus subtilis, was modeled using in silico approaches viz., molecular modelling, protein-protein docking and molecular dynamics simulations. Results identified amino-acid residues present within ...Continue Reading

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