A simple reaction kinetic model of rapid (G protein dependent) and slow (beta-Arrestin dependent) transmission

Journal of Theoretical Biology
Dávid CsercsikGyörgy M Nagy

Abstract

In this paper the qualitative dynamic behavior of reaction kinetic models of G protein signaling is examined. A simplified basic G protein signaling structure is defined, which is extended to be able to take the effect of slow transmission, RGS mediated feedback regulation and ERK-phosphatase mediated feedback regulation into account. The resulting model gives rise to an acceptable qualitative approximation of the G protein dependent and independent ERK activation dynamics that is in good agreement with the experimentally observed behavior.

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Citations

Sep 10, 2009·BMC Systems Biology·Thomas Wilhelm
Jun 28, 2012·Molecular Systems Biology·Domitille HeitzlerEric Reiter

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