A simple, semi-deterministic approximation to the distribution of selective sweeps in large populations

Theoretical Population Biology
Guillaume Martin, Amaury Lambert

Abstract

In large populations, the distribution of the trajectory of allele frequencies under selection and genetic drift approaches a semi-deterministic behavior: a deterministic trajectory started and ended at stochastic boundary values. This provides simple yet accurate approximations for the distribution of allelic frequencies over time (conditional on fixation), and of extinction and fixation times, for both hard and soft sweeps, and under arbitrary inbreeding and dominance.

References

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Dec 5, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Guillaume MartinOphélie Ronce
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Citations

May 18, 2016·Current Biology : CB·Eva J P LievensThomas Lenormand
Mar 30, 2019·Genetics·José Luis Campos, Brian Charlesworth
Sep 19, 2019·Genetics·Luis-Miguel Chevin
Jan 25, 2020·G3 : Genes - Genomes - Genetics·Matthew Hartfield, Thomas Bataillon
Feb 28, 2020·Journal of Mathematical Biology·Jeremy BakerFima C Klebaner
May 14, 2020·Genetics·Matthew M Osmond, Graham Coop
Mar 4, 2018·Genetics·Nuno R NenéChristopher J R Illingworth
Jul 2, 2017·Journal of Mathematical Biology·Pavel ChiganskyFima C Klebaner

Related Concepts

Genetic Equilibrium
Genetics, Population
Neomalthusianism
Selection, Genetic
Stochastic Processes
Evolution, Neutral
Alleles
Inbreeding
Fixation - Action
Genetic Drift

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