A simple strategy to enhance the in vivo wound-healing activity of curcumin in the form of self-assembled nanoparticle complex of curcumin and oligochitosan

Materials Science & Engineering. C, Materials for Biological Applications
Minh-Hiep NguyenKunn Hadinoto

Abstract

While the wound healing activity of curcumin (CUR) has been well-established, its clinical effectiveness remains limited due to the inherently low aqueous CUR solubility, resulting in suboptimal CUR exposure in the wound sites. Previously, we developed high-payload amorphous nanoparticle complex (or nanoplex) of CUR and chitosan (CHI) capable of CUR solubility enhancement by drug-polyelectrolyte complexation. The CUR-CHI nanoplex, however, exhibited poor colloidal stability due to its strong agglomeration tendency. Herein we hypothesized that the colloidal stability could be improved by replacing CHI with its oligomers (OCHI) owed to the better charge distribution in OCHI. The effects of key parameters in drug-polyelectrolyte complexation (i.e. pH, salt inclusion, CUR concentration, and OCHI/CUR charge ratio) on the physical characteristics and preparation efficiency of the CUR-OCHI nanoplex produced were investigated. The in vivo wound healing efficacy of the CUR-OCHI nanoplex and its cytotoxicity towards human keratinocytes cells were examined. The results showed that CUR-OCHI nanoplex exhibited prolonged colloidal stability (72 h versus <24 h for the CUR-CHI nanoplex). At the optimal condition, the CUR-OCHI nanoplex (without...Continue Reading

Citations

Sep 27, 2019·Current Pharmaceutical Design·Gitika A DhingraManju Nagpal
Oct 11, 2020·Polymers·Sibusiso AlvenBlessing Atim Aderibigbe
Oct 22, 2020·Polymers·Zoi TerzopoulouDimitrios Bikiaris
Apr 30, 2020·Mini Reviews in Medicinal Chemistry·Ayushi SethiyaShikha Agarwal
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saravut Satitsri, Chatchai Muanprasat
Sep 22, 2021·Advances in Skin & Wound Care·Pushkar Satish SatheLaura L Bolton
Jun 24, 2021·Current Pharmaceutical Design·Juanjuan ZhaoBing Niu

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