PMID: 17962783Oct 27, 2007

A simple synthetic route to methyl 3-fluoropyridine-4-carboxylate by nucleophilic aromatic substitution

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Freddy Tjosaas, Anne Fiksdahl


The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by fluoride anion via nucleophilic aromatic substitution to give the 3-fluoro- pyridine-4-carboxylate 2.


Nov 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fernanda S PereiraEduardo R P González
Sep 5, 2017·Journal of Labelled Compounds & Radiopharmaceuticals·Falguni BasuliRolf E Swenson
Jul 25, 2019·Chemical Communications : Chem Comm·Myuto KashiharaYoshiaki Nakao

Related Concepts

Methyl 3-fluoropyridine-4-carboxylate
Carboxylic Acids
Isonicotinic Acids

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