Jan 1, 1975

A simple test for early detection of severe renal homograft rejection

Proceedings of the European Dialysis and Transplant Association
R OppolzerH Stummvoll

Abstract

Adding urine to a standard buffered fibrinogen solution and then coagulating it with thrombin gives reproducible coagulation times with normal urines. Coagulation of fibrinogen by thrombin is prolonged in acid solutions with a pH below six. Urines of high acidity lower the buffer pH of the fibrinogen solution below a value of six thus rendering the system uncoagulable or significantly prolonging the coagulation time. With this test system we found that out of 16 severe homograft rejections 15 were accompanied by a high acid excretion in six-hour urine specimens. Ten of these acid episodes became apparent 12 to 48 hr before clinical symptoms and before elevation of the serum creatinine could be detected.

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Mentioned in this Paper

Buffers
Urine
Fibrinogen
Fibrinogen Assay
F2 gene
Thrombin
Kidney
Body Excretions
Graft Rejection
Excretory Function

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