A simple thermal pain model for the evaluation of analgesic activity in healthy subjects.

Journal of Anaesthesiology, Clinical Pharmacology
Sunil Kumar Reddy KhambamT Ramesh Kumar Rao

Abstract

Assessment of the analgesic effect of an agent in an experimental pain model permits a level of control not possible in a clinical pain setting and is an ideal approach for evaluation of analgesic drugs. The aim of the present study was to establish a simple and reliable method of producing experimental pain, which can be used for screening of various analgesic agents. The standardized method was followed in all cases, by recording thermal pain threshold in seconds in 24 healthy volunteers using hot air source at two different speeds, which is equipped in an acrylic-made chamber adjustable to three different levels. Reproducibility of the test procedure was evaluated by recording the thermal threshold parameter by a single observer on two sessions (interday reproducibility) and second observer on one session (interobserver reproducibility) separately. Validity of model was further tested by evaluating the analgesic effect of tramadol on 12 healthy volunteers. Thermal pain model was found to produce low variability with coefficient of variation (CV) less than 10%. Interobserver and interday reproducibility were very good, as shown by Bland-Altman plot, with most of the values within ± 2SD. There was a significant increase in pai...Continue Reading

Citations

Apr 30, 2014·European Journal of Pain : EJP·F MahnA Binder

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