A simple transfer function for nonlinear dendritic integration

Frontiers in Computational Neuroscience
Matthew F Singh, David H Zald

Abstract

Relatively recent advances in patch clamp recordings and iontophoresis have enabled unprecedented study of neuronal post-synaptic integration ("dendritic integration"). Findings support a separate layer of integration in the dendritic branches before potentials reach the cell's soma. While integration between branches obeys previous linear assumptions, proximal inputs within a branch produce threshold nonlinearity, which some authors have likened to the sigmoid function. Here we show the implausibility of a sigmoidal relation and present a more realistic transfer function in both an elegant artificial form and a biophysically derived form that further considers input locations along the dendritic arbor. As the distance between input locations determines their ability to produce nonlinear interactions, models incorporating dendritic topology are essential to understanding the computational power afforded by these early stages of integration. We use the biophysical transfer function to emulate empirical data using biophysical parameters and describe the conditions under which the artificial and biophysically derived forms are equivalent.

References

Jan 22, 1991·Proceedings. Biological Sciences·A J Gibb, D Colquhoun
May 29, 1998·Biological cybernetics·M Ohme, A Schierwagen
Apr 10, 1999·Nature Neuroscience·J KangM Nedergaard
Apr 5, 2000·Nature·J SchillerY Schiller
Apr 3, 2003·Neuron·Panayiota PoiraziBartlett W Mel
Jul 10, 2003·Current Opinion in Neurobiology·Michael Häusser, Bartlett Mel
May 25, 2004·Nature Neuroscience·Alon PolskyJackie Schiller
May 27, 2004·Nature Neuroscience·Nelson Spruston, William L Kath
Jun 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephen R Williams
Sep 15, 2009·PLoS Computational Biology·Balázs UjfalussyPéter Erdi
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alon PolskyJackie Schiller
May 21, 2010·PLoS Computational Biology·Ronald A J van Elburg, Arjen van Ooyen
Jun 15, 2010·Journal of Neuroscience Research·Srdjan D AnticKaterina D Ikonomu
Aug 31, 2010·Current Opinion in Neurobiology·Tiago Branco, Michael Häusser
Mar 9, 2011·Neuron·Tiago Branco, Michael Häusser
Aug 16, 2011·Journal of Computational Neuroscience·Gilles WainribKhashayar Pakdaman
Dec 16, 2011·Frontiers in Computational Neuroscience·José Francisco Gómez GonzálezPanayiota Poirazi
Jun 22, 2012·PLoS Computational Biology·Monika JadiBartlett W Mel
Sep 17, 2013·Biological cybernetics·Willem A M WyboBenjamin Torben-Nielsen
Dec 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Bardia F Behabadi, Bartlett W Mel

❮ Previous
Next ❯

Citations

Nov 18, 2017·The Journal of Physiology·Violeta MedanThomas Preuss

❮ Previous
Next ❯

Software Mentioned

MatLab2015a

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cellular and Molecular Life Sciences : CMLS
Rebecca A Piskorowski, Vivien Chevaleyre
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
G Stuart, N Spruston
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Conrad W Liang
© 2021 Meta ULC. All rights reserved