PMID: 853971Jan 1, 1977

A simple universal mechanism of use and conservation of energy: its application to movements of ions and other materials across cell, mitochondrial and other membranes and to oxidative phosphorylation

Medical Hypotheses
A EvanP M Wiggins

Abstract

A single simple mechanism by which all cells might both use energy to drive active transport to all solutes and also conserve energy in the form of adenosinetriphosphate (ATP) is descirbed. The basic assumption is that injection of energy results in a conformational change of the membrane which both generates transient highly-ordered water structures on its inside surface and changes membrane permeability. Ordered water is propagated through the cell by means of cooperative interactions with proteins, so that during the ordered period intracellular water is incompatible with small cations which require strong primary hydration, but has enhanced affinity for water-structure-breaking solutes. In animal cells cytoplasmic water is ordered by the activity of the plasma-membrane-bound transport ATPases. In mitochondria and bacteria the state of ordered water is identified with the energised state, which can be generated either by passage of electrons down the electron chain, or by ATPase activity. The mechanism is shown to be consistent with the observed transport activities of mitochondria and bacteria, and also provides a simple direct explanation of oxidative phosphorylation.

References

Oct 1, 1982·Journal of Learning Disabilities·A J Harris

Citations

Mar 25, 1976·Biochimica Et Biophysica Acta·S F Hannan, P M Wiggins
Jul 1, 1975·Journal of Theoretical Biology·P M Wiggins
Mar 1, 1975·Medical Hypotheses·P M Wiggins
Jan 1, 1975·Annual Review of Biochemistry·R D Simoni, P W Postma
Nov 1, 1975·Medical Hypotheses·P M Wiggins
Dec 1, 1968·The Journal of Physiology·A F Lant, R Whittam
Apr 1, 1969·The Journal of Physiology·H J Schatzmann, F F Vincenzi
Jan 1, 1969·Annual Review of Biochemistry·H A Lardy, S M Ferguson
Feb 18, 1974·Annals of the New York Academy of Sciences·F M Harold
Oct 31, 1974·Biochimica Et Biophysica Acta·L Kovác
Dec 30, 1974·Biochimica Et Biophysica Acta·V D Gooch, L Packer
Jul 1, 1971·Journal of Theoretical Biology·P M Wiggins
Feb 18, 1974·Annals of the New York Academy of Sciences·F J LombardiH R Kaback
Jun 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H HirataF M Harold
Dec 30, 1974·Biochimica Et Biophysica Acta·A J Meijer, K Van Dam
Nov 1, 1972·Journal of Theoretical Biology·P M Wiggins
Nov 7, 1972·European Journal of Biochemistry·H W HeldtM Milovancev
Nov 5, 1973·Journal of Theoretical Biology·P M Wiggins
Aug 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J B Hanson, R J Miller
Jun 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·J T Tupper, H Tedeschi
Aug 1, 1966·Biological Reviews of the Cambridge Philosophical Society·P MITCHELL
Nov 1, 1970·Journal of Theoretical Biology·B E Banks, C A Vernon

Related Concepts

Tissue Membrane
Calcium
Adenosine Triphosphatases
Energy Metabolism
Protoplasm
Potassium
Macromolecular Alteration
Hydrogen
Cations
Mitochondria

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