A Simpler Energy Transfer Efficiency Model to Predict Relative Biological Effect for Protons and Heavier Ions

Frontiers in Oncology
B Jones

Abstract

The aim of this work is to predict relative biological effectiveness (RBE) for protons and clinically relevant heavier ions, by using a simplified semi-empirical process based on rational expectations and published experimental results using different ion species. The model input parameters are: Z (effective nuclear charge) and radiosensitivity parameters αL and βL of the control low linear energy transfer (LET) radiation. Sequential saturation processes are assumed for: (a) the position of the turnover point (LETU) for the LET-RBE relationship with Z, and (b) the ultimate value of α at this point (αU) being non-linearly related to αL. Using the same procedure for β, on the logical assumption that the changes in β with LET, although smaller than α, are symmetrical with those of α, since there is symmetry of the fall off of LET-RBE curves with increasing dose, which suggests that LETU must be identical for α and β. Then, using iso-effective linear quadratic model equations, the estimated RBE is scaled between αU and αL and between βU and βL from for any input value of Z, αL, βL, and dose. The model described is fitted to the data of Barendsen (alpha particles), Weyrather et al. (carbon ions), and Todd for nine different ions (de...Continue Reading

References

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Feb 27, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Herman SuitAlexei Trofimov
Dec 18, 2010·International Journal of Radiation Oncology, Biology, Physics·Clemens GrassbergerHarald Paganetti
Jul 20, 2011·Acta Oncologica·Brita Singers SørensenNiels Bassler
Feb 15, 2012·Physics in Medicine and Biology·Alejandro CarabeHarald Paganetti
Mar 6, 2012·The British Journal of Radiology·B JonesR G Dale
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Apr 4, 2013·The British Journal of Radiology·M DosanjhS Myers
Feb 2, 2015·The Lancet Oncology·Tadashi KamadaWilliam T Chu

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Citations

Jul 18, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Camilla H StokkevågLudvig P Muren
Mar 16, 2017·Medical Physics·Eivind RørvikKristian S Ytre-Hauge
Aug 19, 2017·Acta Oncologica·B Jones
Aug 14, 2018·Physics in Medicine and Biology·Eivind RørvikKristian S Ytre-Hauge
Nov 13, 2018·Physics in Medicine and Biology·T J DahleA Mairani
Jan 10, 2019·Journal of Radiation Research·Ming Tsuey ChewAndrew Nisbet
Jul 30, 2019·Physics in Medicine and Biology·Eivind RørvikKristian S Ytre-Hauge
Oct 13, 2020·Frontiers in Oncology·Bleddyn Jones
Jan 12, 2021·Physics in Medicine and Biology·Stephen J McMahon
Sep 16, 2021·International Journal of Radiation Biology·Joshua W MooreBleddyn Jones

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