PMID: 7030050Nov 1, 1981Paper

A simplified approach to lipoprotein kinetics and factors affecting serum cholesterol and triglyceride concentrations

The American Journal of Clinical Nutrition
P N Hopkins, R R Williams

Abstract

Serum lipoproteins have received considerable notoriety as risk factors for atherosclerotic disease, yet the kinetic factors that determine serum concentrations are often unappreciated. Simple compartmental models for lipoprotein kinetics are herein presented which integrate key features of lipoprotein metabolism and allow prediction of very low-density lipoprotein and low-density lipoprotein levels in a wide variety of clinical circumstances. Possible changes in kinetic parameters responsible for hyperlipidemia in obesity, insulin resistance, diabetes, carbohydrate (sugar)-induced hypertriglyceridemia, alcoholic type V hyperlipemia, polyunsaturated fat diets, and several pharmacological interventions are discussed. Key features of lipoprotein metabolism are briefly reviewed.

Associated Clinical Trials

Citations

May 6, 2004·Medicine and Science in Sports and Exercise·Béatrice MorioRobert R Wolfe
Jun 1, 1985·The American Journal of Physiology·R R WolfeM J Durkot
Jul 1, 1987·The American Journal of Physiology·G J BagbyR R Martinez
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·B MittendorferL S Sidossis
Jun 1, 1988·Journal of Hepatology·A AvgerinosN McIntyre

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