A simplified definition of diastolic function in sepsis, compared against standard definitions

Journal of Intensive Care
Michael J LanspaColin K Grissom

Abstract

Guidelines for grading diastolic dysfunction poorly categorize septic patients. We compared how well the American Society of Echocardiography (ASE) 2009 and 2016 definitions and a simplified definition categorized septic patients. We studied septic patients who received a transthoracic echocardiogram within 24 h of admission to an ICU. We categorized patients according to ASE 2009 and 2016 definitions and a definition using E/e', a surrogate for left ventricular filling pressure. We assessed 28-day all-cause mortality and the presence of pre-existing diabetes, hypertension, or myocardial infarction. We tested for associations among diastolic grade, comorbidities, and outcomes using logistic regression. We studied 398 patients. Mortality was 23%. The simplified definition categorized more patients than ASE 2016 (78% vs. 71%, p = 0.035); both definitions categorized more patients than ASE 2009 (34%, p < 0.001 for both comparisons). Higher grades of diastolic dysfunction were associated with hypertension (ASE 2016, simplified), myocardial infarction (ASE 2009, simplified), and diabetes (simplified). Grade of diastolic dysfunction was not associated with mortality by any definition. Of 199 patients categorized as normal by ASE 2016...Continue Reading

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Citations

Dec 18, 2020·Revista da Associação Médica Brasileira·Marcus G BastosArise Gs Galil
Oct 18, 2020·Chest·Michael J LanspaColin K Grissom
Apr 29, 2021·Arquivos brasileiros de cardiologia·Devrim BozkurtSalih Kilic

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