Abstract
Twenty-one nondiabetic subjects, their weights ranging from 56 to 165 kg, received an infusion of glucose (420 mg/min), insulin (0.77 mU/kg/min), and somatostatin (500 microgram/h) for 150 min. A steady state level of plasma insulin and glucose was attained after 90 min. Endogenous insulin secretion determined by C-peptide measurement, and glucagon secretion remained suppressed throughout the period. With similar steady state levels of plasma insulin (SSPI) maintained in all subjects, the height of the steady state plasma glucose concentration (SSPG) was considered an index of total body sensitivity to insulin-mediated glucose uptake. A positive correlation between SSPG and the degree of obesity, as determined by the body mass index (BMI), was demonstrated (r = 0.70, P less than 0.001). No correlation was found between SSPI and BMI. The fasting plasma insulin concentration correlated with BMI (r = 0.82, P less than 0.0001) and SSPG (r = 0.80, P less than 0.0001). This method provides a simple safe measure of total body insulin resistance over a wide range of obesity and is independent of endogenous insulin secretion.
Citations
Jun 1, 1987·Diabetologia·R M LampmanW D Block
Jul 1, 1991·Diabetologia·P FerrariP Weidmann
Jan 1, 1984·Metabolism: Clinical and Experimental·D J EvansA H Kissebah
Oct 1, 1986·Computer Methods and Programs in Biomedicine·G Pacini, R N Bergman
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A WajngotS Efendić
Mar 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·T KawasakiM Uchiyama
Jul 1, 1991·Clinical Endocrinology·J U WeaverP G Kopelman
Sep 1, 1993·Clinical Endocrinology·J U WeaverA Grossman
Apr 1, 1992·European Journal of Clinical Investigation·J U WeaverG A Hitman
Sep 28, 1991·BMJ : British Medical Journal·E T SkarforsH O Lithell
Oct 1, 1984·The Journal of Clinical Investigation·D J EvansA H Kissebah
Jun 1, 1985·Journal of Endocrinological Investigation·A Carducci ArtenisioF Consolo
Jan 1, 1992·Journal of Internal Medicine·A Laws, G M Reaven
Sep 18, 2009·Developmental Medicine and Child Neurology·William A Bauman
Nov 13, 2004·Metabolism: Clinical and Experimental·Daniel A Garca-EstévezJosé Cabezas-Cerrato
Jul 1, 1984·The American Journal of Medicine·T A HughesG White
Oct 1, 1992·The American Journal of the Medical Sciences·C Arauz-PachecoP Raskin
Jun 10, 2004·Patient Education and Counseling·Barend J C Middelkoop, Gerrit van der Wal
Nov 26, 1999·Clinical and Experimental Hypertension : CHE·M SuzukiY Harano
Jan 1, 1987·Annals of the New York Academy of Sciences·B Caballero
Jan 1, 1988·Acta Medica Scandinavica·M KollindP E Lins
Sep 1, 1983·American Journal of Physical Anthropology·W C KnowlerR C Williams
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M P Stern, S M Haffner
Jul 1, 1994·Diabetes/metabolism Reviews·A J ScheenP J Lefèbvre
Mar 1, 1985·The American Journal of Physiology·C BogardusG Reaven
May 1, 1986·The American Journal of Physiology·C CobelliL Saccà
Jun 1, 1981·The American Journal of Physiology·R A RizzaJ E Gerich
Oct 13, 1998·Annals of Clinical Biochemistry·D C Whitelaw, S G Gilbey
Sep 1, 1984·The American Journal of Physiology·R N BergmanG Pacini
Jan 1, 1981·The American Journal of Medicine·R A RizzaJ E Gerich