A simplified noninvasive method to measure airway blood flow in humans

Journal of Applied Physiology
A WannerN D Atkins

Abstract

Our laboratory has previously developed and validated a noninvasive soluble gas uptake method to measure airway blood flow (Qaw) in humans (Onorato DJ, Demirozu MC, Breitenbücher A, Atkins ND, Chediak AD, and Wanner A. Am J Respir Crit Care Med 149: 1132-1137, 1994; Scuri M, McCaskill V, Chediak AD, Abraham WM, and Wanner A. J Appl Physiol 79: 1386-1390, 1995). The method has the disadvantage of requiring eight breath-hold maneuvers for a single Qaw measurement, a complicated data analysis, and the inhalation of a potentially explosive gas mixture containing dimethylether (DME) and O2. Because of these shortcomings, the method thus far has not been used in other laboratories. We now simplified the method by having the subjects inhale 500 ml of a 10% DME-90% N2 gas mixture to fill the anatomical dead space, followed by a 5- or 15-s breath hold, and measuring the instantaneous DME and N2 concentrations and volume at the airway opening during the subsequent exhalation. From the difference in DME concentration in phase 1 of the expired N2 wash-in curve multiplied by the phase 1 dead space volume and divided by the mean DME concentration and the solubility coefficient for DME in tissue, Qaw can be calculated by using Fick's equation...Continue Reading

References

May 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·B T PetersonB F Schreiner
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·D J OnoratoA Wanner
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·S D KumarA Wanner
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·J L BrievaA Wanner
Feb 13, 2001·Journal of Applied Physiology·J Brieva, A Wanner
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Jan 1, 1952·The Journal of Clinical Investigation·W S FOWLERS S KETY
Mar 19, 2004·American Journal of Respiratory and Critical Care Medicine·Eliana S MendesAdam Wanner
Sep 27, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Donald W McRobbie, Susan E Pritchard

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Citations

Oct 22, 2009·Analytical and Bioanalytical Chemistry·Audrey N MartinMatthias Frank
Sep 25, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mohammad A KhanMark R Nicolls
Jul 10, 2012·Journal of Applied Physiology·Kenneth C BeckTheodore A Wilson
Aug 17, 2010·American Journal of Respiratory and Critical Care Medicine·Adam Wanner, Eliana S Mendes
Apr 28, 2009·Respiratory Care·Jane C Davies, Eric Wfw Alton
Apr 17, 2014·Annals of the American Thoracic Society·Eliana S MendesAdam Wanner
May 7, 2011·Respiratory Physiology & Neurobiology·Maile L CeridonBruce D Johnson
Oct 6, 2009·Pulmonary Pharmacology & Therapeutics·Pär EwingPer Gerde
May 26, 2009·Medical Hypotheses·Maile CeridonBruce D Johnson
Jul 12, 2011·Respiratory Physiology & Neurobiology·Maile L CeridonBruce D Johnson
Apr 19, 2015·BMC Pharmacology & Toxicology·Jose E CancadoAdam Wanner
May 10, 2008·Journal of Applied Physiology·Eliana S MendesAdam Wanner
Aug 28, 2019·Exercise and Sport Sciences Reviews·Sophie LalandeBryan J Taylor
Jan 12, 2013·Journal of Applied Physiology·Michael P HlastalaJoseph C Anderson

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