PMID: 5164952Jun 1, 1971Paper

A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain

The Biochemical Journal
C J van den Berg, D Garfinkel

Abstract

A computer model of the metabolism of glutamate, glutamine, gamma-aminobutyrate, and the tricarboxylic acid cycle in mouse brain has been constructed in terms of 39 reactions among 19 substances or groups of substances (permitting manipulation of 30 independent variables). The model is divided into two compartments, in conformity with previous models based on indirect evidence, and it is found that this compartmentation is indeed the same as that indicated directly with specifically (14)C-labelled acetate and glucose. The movement of materials between the large and small compartments has been studied; glutamine appears to flow from the small to the large compartment, gamma-aminobutyrate in the reverse direction.

Citations

Mar 14, 2012·The Journal of Physiology·Nneka M UwechueBrian Billups
Dec 1, 1989·Journal of Neuroscience Research·E Tiffany-CastiglioniL V Sheeler-Gough
Jul 1, 1990·Annals of Neurology·J D RothsteinJ T Coyle
Oct 1, 1992·Journal of Neuroscience Research·L HertzA Schousboe
Jul 1, 1974·Journal of Neurochemistry·P J Roberts, P Keen
Sep 25, 2004·Glia·Angelika BröerStefan Bröer
Nov 24, 2011·Neurochemistry International·Puneet Bagga, Anant Bahadur Patel
Oct 18, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sébastien SerresMichel Merle
Mar 30, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peggy ProventJonathan A Coles
Oct 13, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Elisabeth OlstadUrsula Sonnewald
Jan 13, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fahmeed HyderRobert G Shulman
Mar 16, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Torun M MeløAstrid Nehlig
Mar 1, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maha El HageGuy Martin
Jul 29, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rossana OcchipintiDaniela Calvetti
Feb 4, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anant B PatelGraeme F Mason
May 28, 2015·Neurochemical Research·John T Hackett, Tetsufumi Ueda
Nov 17, 2007·Neurochemistry International·Paul K Maciejewski, Douglas L Rothman
Jul 28, 2005·Journal of Neurochemistry·Eiliv BrennerUrsula Sonnewald
Jul 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Fawzi BoumezbeurVincent Lebon
May 20, 2003·Journal of Neurochemistry·Haytham EloqayliUrsula Sonnewald
Mar 19, 2003·Journal of Neurochemistry·Daniel KondziellaUrsula Sonnewald
May 15, 2007·Journal of Neuroscience Research·Lasse K BakHelle S Waagepetersen
Jun 22, 2006·Journal of Neurochemistry·Lasse K BakHelle S Waagepetersen
Jan 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C I H C NabuursA Heerschap
Jul 8, 2008·Journal of Neuroendocrinology·E Hrabovszky, Z Liposits
May 7, 2009·Journal of Neurochemistry·Dinesh K DeelchandPierre-Gilles Henry
Sep 12, 2007·Journal of Neuroscience Research·Mary C McKenna
Jun 25, 1976·Brain Research·H F Bradford, H K Ward
May 18, 2012·Glia·Douglas A Coulter, Tore Eid
Apr 27, 2011·Journal of Neurochemistry·María C Hyzinski-GarcíaAlexander A Mongin
Oct 27, 2004·The Science of the Total Environment·Keith M EriksonMichael Aschner

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