A Simulation Study of Relative Efficiency and Bias in the Nested Case-Control Study Design

Epidemiologic Methods
Stephen BertkeJames Deddens

Abstract

The nested case-control study design, in which a fixed number of controls are matched to each case, is often used to analyze exposure-response associations within a cohort. It has become common practice to sample four or five controls per case; however, previous research has shown that in certain instances, significant gains in relative efficiency can be realized when more controls are matched to each case. This study expanded upon this and investigated the effect of (i) the number of cases, (ii) the strength of the exposure-response, and (iii) the skewness of the exposure distribution on the bias and relative efficiency of the conditional likelihood estimator from a nested case-control study. Cohorts were simulated and analyzed using conditional logistic regression. The relative efficiency decreased and bias away from the null increased, as the true exposure-response parameter increased and the skewness of the exposure distribution of the risk-sets increased. This became more pronounced when the number of cases in the cohort was small. Gains in relative efficiency and a reduction in bias can be realized by sampling more than four or five controls per case generally used, especially when there are few cases, a strong exposure-r...Continue Reading

References

Oct 1, 1978·American Journal of Epidemiology·N E BreslowC Sabai
Nov 1, 1976·Journal of Chronic Diseases·M GailC Brown
Aug 1, 1987·Plastic and Reconstructive Surgery·V VelanovichN Koss
Apr 23, 1987·The New England Journal of Medicine·R A RinskyP J Landrigan
Oct 1, 1995·American Journal of Public Health·K Steenland, D Brown
Oct 13, 2004·Occupational and Environmental Medicine·D B Richardson, D Loomis
Mar 18, 2009·Epidemiology·Misty J HeinMary K Schubauer-Berigan

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Citations

Nov 3, 2015·American Journal of Industrial Medicine·James H YiinLeslie T Stayner
Dec 4, 2016·International Journal of Cancer. Journal International Du Cancer·Robert D DanielsMary K Schubauer-Berigan
Feb 2, 2018·International Journal of Epidemiology·Bénédicte DelcoigneMarie Reilly
Dec 5, 2019·International Journal of Environmental Research and Public Health·Mohammad Mojibul Hoque MozumderMohammad Mahmudul Islam
Dec 10, 2016·BMC Medical Informatics and Decision Making·David L Paul, Reuben R McDaniel
Nov 30, 2016·Maternal & Child Nutrition·Danielle GroleauSonia Semenic
Dec 4, 2016·Global Health Action·Richard VergunstStine Hellum Braathen
Dec 20, 2017·Archives of public health = Archives belges de santé publique·Praveen KumarGautam N Yadama
Jan 5, 2018·Archives of Sexual Behavior·Anthony MorganRenata Arrington Sanders
Sep 21, 2015·Administration and Policy in Mental Health·Cathleen E WillgingDebra B Hecht
May 14, 2019·International Quarterly of Community Health Education·Ithar HassaballaKoffi Kouadio
Aug 25, 2017·Disability and Rehabilitation. Assistive Technology·Fatima Fanna MairamiDaniel Diamond Reidpath
Oct 30, 2018·Augmentative and Alternative Communication : AAC·Amie T KronStephen E Ryan
Mar 11, 2017·Journal of the Air & Waste Management Association·Jana B Milford, Daniel Knight
Apr 13, 2017·Disability and Rehabilitation·Surona Visagie, Leslie Swartz
Jun 5, 2018·Journal of Applied Animal Welfare Science : JAAWS·Taryn M Graham, Melanie J Rock
Nov 23, 2015·Advances in Health Sciences Education : Theory and Practice·Caroline C P OngDebra Nestel
Mar 22, 2016·Contemporary Nurse·Sue DeanMark Balnaves
May 6, 2016·Frontiers in Public Health·Matthew Lee SmithMarcia G Ory
Mar 6, 2018·International Journal of Health Care Quality Assurance·Chantal BackmanAlan J Forster
May 18, 2018·Leadership in Health Services·Tracy H PorterScott J Allen
Apr 4, 2017·Health & Social Care in the Community·Heather Yoeli, Mima Cattan
May 18, 2016·American Journal of Epidemiology·Rishi J DesaiJoshua J Gagne

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