A simulation study of the efficacy of stepwise discriminant analysis in the detection and comparison of event related potentials

Electroencephalography and Clinical Neurophysiology
E Donchin, R I Herning

Abstract

Cortical average evoked potentials were simulated by summing five damped sinusoids. The characteristics of these "evoked" responses could be manipulated by changing parameters of the sinusoids. The synthesized signals were mixed with noise processes whose power and band-width were manipulated. Thus data were generated to stimulate a variety of conditions which could conceivably occur in an experiment on evoked potentials. Stepwise discriminant analysis (BMD07M) has been applied to these simulated data in an attempt to determine the degree to which the program identifies, in a sensible manner, the differences we introduced into the synthesized evoked responses. The simulation results indicate that stepwise discriminant analysis can indeed be an efficacious tool in research on evoked potentials. The program does detect differences in evoked potentials. It can be used, with some reservations, to identify the components of an evoked potential which the experimental variables have affected. In a special set of simulations we have attempted to determine the degree to which stepwise discriminant analysis could serve to detect the presence or absence of an evoked potential. These simulations show that the score of an average evoked pot...Continue Reading

References

Jan 1, 1989·Brain Topography·P E RappA I Mees
May 1, 1975·Electroencephalography and Clinical Neurophysiology·E DonchinE Heffley
Aug 1, 1976·Electroencephalography and Clinical Neurophysiology·W S BrownJ C Smith
Nov 1, 1976·Electroencephalography and Clinical Neurophysiology·K C Squires, E Donchin
Jan 1, 1977·Electroencephalography and Clinical Neurophysiology·K C SquiresG McCarthy
Mar 1, 1978·Electroencephalography and Clinical Neurophysiology·J D WickeT Allison
Nov 1, 1980·Electroencephalography and Clinical Neurophysiology·I Yaar
Feb 1, 1980·Electroencephalography and Clinical Neurophysiology·R L Horst, E Donchin
Mar 1, 1984·International Journal of Bio-medical Computing·J VitraiS Marosfi
Nov 1, 1988·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J P O'HalloranL S Larkey
Jun 1, 1996·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J RöschkeC Frank
Oct 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·A PiersonD Widlöcher
Feb 19, 2002·Journal of Neuroscience Methods·Haluk UtkuSirel Karakaş
Mar 1, 1986·Electroencephalography and Clinical Neurophysiology·S Ziganow
Feb 1, 1989·Acta Psychologica·E J SirevaagE Donchin
Dec 1, 1986·IEEE Transactions on Bio-medical Engineering·J M Moser, J I Aunon
Dec 1, 1986·IEEE Transactions on Bio-medical Engineering·D G ChildersA A Arroyo
Jan 1, 1978·CRC Critical Reviews in Clinical Laboratory Sciences·H E Solberg
Jul 1, 1985·The International Journal of Neuroscience·C R ChapmanW K Dong

Citations

Nov 1, 1970·Electroencephalography and Clinical Neurophysiology·E DonchinR T Jones
Jun 1, 1967·Electroencephalography and Clinical Neurophysiology·E Donchin, L Cohen
Sep 1, 1969·Electroencephalography and Clinical Neurophysiology·E Donchin
Feb 7, 1969·Science·J M MillerW C Stebbins
Jul 1, 1966·IEEE Transactions on Bio-medical Engineering·E Donchin
Sep 27, 1963·Science·E DonchinD B LINDSLEY

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