A simultaneous multichannel monophasic action potential electrode array for in vivo epicardial repolarization mapping

IEEE Transactions on Bio-medical Engineering
A V SahakianS Swiryn

Abstract

While the recording of extracellular monophasic action potentials (MAPs) from single epicardial or endocardial sites has been performed for over a century, we are unaware of any previous successful attempt to record MAPs simultaneously from a large number of sites in vivo. We report here the design and validation of an array of MAP electrodes which records both depolarization and repolarization simultaneously at up to 16 epicardial sites in a square array on the heart in vivo. The array consists of 16 sintered Ag-AgCl electrodes mounted in a common housing with individual suspensions allowing each electrode to exert a controlled pressure on the epicardial surface. The electrodes are arranged in a square array, with each quadrant of four having an additional recessed sintered Ag-AgCl reference electrode at its center. A saline-soaked sponge establishes ionic contact between the reference electrodes and the tissue. The array was tested on six anesthetized open-chested pigs. Simultaneous diagnostic-quality MAP recordings were obtained from up to 13 out of 16 ventricular sites. Ventricular MAPs had amplitudes of 10-40 mV with uniform morphologies and stable baselines for up to 30 min. MAP duration at 90% repolarization was measured...Continue Reading

References

Feb 1, 1990·Pacing and Clinical Electrophysiology : PACE·N KanaanA Kadish
May 1, 1991·Progress in Cardiovascular Diseases·M R Franz
Oct 1, 1990·Journal of the American College of Cardiology·M R FranzM M Scheinman
Mar 1, 1994·Journal of Cardiovascular Electrophysiology·S YuanS B Olsson

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