PMID: 8970965Dec 1, 1996Paper

A single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with the ability to cause growth hormone deficiency syndrome

Journal of Virology
M N TengJ C de la Torre

Abstract

Persistent infection of C3H/St mice with certain strains of lymphocytic choriomeningitis virus (LCMV) causes a growth hormone (GH) deficiency syndrome (GHDS) manifested as growth retardation and hypoglycemia. Infected mice show high levels of viral replication in the GH-producing cells in the anterior pituitary leading to decreased synthesis of GH mRNA and protein despite the absence of detectable virus-induced cell structural damage. Virus clones isolated from the GHDS-negative LCMV WE strain can cause the disease, while others cannot. The genetic basis of this phenotypic difference is a nucleotide substitution resulting in a single amino acid difference in the viral glycoprotein. Reassortant studies indicate that the single amino acid substitution (Ser-153 to Phe) is sufficient to allow infection of the GH-producing cells and cause GHDS. These results show that a single change in the genome can affect viral pathogenicity by altering the tropism of the virus.

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Citations

Apr 23, 2002·Journal of Virology·Christina F SpiropoulouMichael B A Oldstone
Jan 21, 2009·Journal of Virology·François-Loic CossetBirke Bartosch
Mar 21, 2009·Nature Protocols·Robert H KutnerJakob Reiser
Jun 3, 2008·Stem Cells and Development·David M RicksJakob Reiser
Jun 8, 2012·The Journal of Veterinary Medical Science·Masayuki Shimojima, Yoshihiro Kawaoka
Jan 25, 2013·Viruses·Juan C Zapata, Maria S Salvato
May 17, 2000·The Journal of General Virology·J Schneider-Schaulies
Mar 23, 2012·Journal of Virology·Linda G BrockUrsula J Buchholz
Nov 9, 2000·The Journal of Experimental Medicine·N SevillaM B Oldstone
Apr 26, 2016·Nature Structural & Molecular Biology·Kathryn M HastieErica Ollmann Saphire
Jun 3, 2017·Science·Kathryn M HastieErica Ollmann Saphire
Aug 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Brian C WareMichael B A Oldstone
Jun 11, 1999·Journal of Virology·H MileticD von Laer
Jan 1, 1997·Brain Research Bulletin·D Gonzalez-DuniaJ C de la Torre
Apr 23, 2003·Virology·Carmen M Ruiz-JaraboJuan Carlos de la Torre

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