PMID: 9525611Apr 3, 1998Paper

A single amino acid change in the hemagglutinin protein of measles virus determines its ability to bind CD46 and reveals another receptor on marmoset B cells

Journal of Virology
E C HsuC D Richardson

Abstract

This paper provides evidence for a measles virus receptor other than CD46 on transformed marmoset and human B cells. We first showed that most tissues of marmosets are missing the SCR1 domain of CD46, which is essential for the binding of Edmonston measles virus, a laboratory strain that has been propagated in Vero monkey kidney cells. In spite of this deletion, the common marmoset was shown to be susceptible to infections by wild-type isolates of measles virus, although they did not support Edmonston measles virus production. As one would expect from these results, measles virus could not be propagated in owl monkey or marmoset kidney cell lines, but surprisingly, both a wild-type isolate (Montefiore 89) and the Edmonston laboratory strain of measles virus grew efficiently in B95-8 marmoset B cells. In addition, antibodies directed against CD46 had no effect on wild-type infections of marmoset B cells and only partially inhibited the replication of the Edmonston laboratory strain in the same cells. A direct binding assay with insect cells expressing the hemagglutinin (H) proteins of either the Edmonston or Montefiore 89 measles virus strains was used to probe the receptors on these B cells. Insect cells expressing Edmonston H ...Continue Reading

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Citations

Feb 7, 2001·Journal of Virology·M ManchesterM B Oldstone
May 17, 2000·The Journal of General Virology·J Schneider-Schaulies
Sep 6, 2000·Nature·H TatsuoY Yanagi
Sep 20, 2001·The Journal of General Virology·C H WoelkD W Brown
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May 15, 2002·Microbiology and Immunology·Hironobu Tatsuo, Yusuke Yanagi
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Apr 15, 2003·The Journal of General Virology·Oliver AndresJürgen Schneider-Schaulies
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Jan 6, 2009·Uirusu·Takao HashiguchiYusuke Yanagi
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Aug 25, 2012·Uirusu·Maino Tahara, Makoto Takeda
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Jan 11, 2020·Critical Reviews in Biotechnology·Daniel LoewePeter Czermak

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