A single-center cohort study to define the role of pretransplant biopsy score in the long-term outcome of kidney transplantation

Transplantation
Vincenzo LosappioG Grandaliano

Abstract

The role of pretransplant biopsy in defining the quality of kidney grafts is still debated. The aim of this study was to investigate the influence of pretransplant biopsy score on long-term graft outcome. In a retrospective cohort study, we analyzed 372 recipients of single kidney transplantation (SKT) from deceased donors between 1997 and 2007, with an available pretransplant biopsy. We evaluated 5- and 10-year graft survival, incidence of delayed graft function, and estimated glomerular filtration rate at 1 and 5 years. Graft survival at 5 and 10 years was significantly better for recipients with a score of 0 compared to transplants with a score of 1 to 5, whereas we did not observe any significant difference among transplants with a score of 1 through 4. Survival of kidneys with a score of 5 was significantly worse compared to grafts with a score of 1 to 4. In a multivariate Cox model, only pretransplant histological score was significantly associated with graft survival. Transplants with a score of 0 and 5 had the best and the worst graft function, respectively, both at 1 and 5 years, whereas we did not observe any difference among patients with a score of 1 through 4. In a multivariate logistic regression, pretransplant hi...Continue Reading

References

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Citations

Aug 27, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I GandolfiniU Maggiore
Dec 30, 2014·BMC Nephrology·Carlo GrifasiAndrea Renda
Jan 11, 2017·Transplantation·María José Pérez-SáezJulio Pascual
Apr 14, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Ana Sánchez-EscuredoFederico Oppenheimer
Jan 13, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Benedict L PhillipsChris J Callaghan
Dec 17, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Maria MessinaLuigi Biancone
Aug 15, 2019·Clinical Kidney Journal·Giovanni Stallone, Giuseppe Grandaliano
May 12, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Giovanni Stallone, Giuseppe Grandaliano
Aug 28, 2018·World Journal of Transplantation·Giacomo ColussiFabio Rosario Salerno

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