A Single-Center Prospective Cohort Study on Postsplenectomy Sepsis and its Prevention

Open Forum Infectious Diseases
Siegbert RiegChristian Theilacker

Abstract

This study evaluated the impact of a dedicated outpatient service on vaccination uptake after splenectomy and on the incidence of postsplenectomy sepsis. From 2009 to 2016 at the University Hospital Freiburg (Germany), asplenic patients were referred to a dedicated outpatient service, provided with comprehensive preventive care including vaccinations, and enrolled in a prospective cohort study. The impact of the service on vaccination uptake and the occurrence of severe sepsis/septic shock was compared between patients who had splenectomy (or were asplenic) within 3 months of study entry ("early study entry") and those who had splenectomy (or were asplenic) >3 months before study entry ("delayed study entry"). A total of 459 asplenic patients were enrolled, and 426 patients were followed prospectively over a median period of 2.9 years. Pneumococcal vaccine uptake within 3 months of splenectomy or first diagnosis of asplenia was 27% vs 71% among delayed study entry and early study entry patients, respectively (P < .001). Forty-four episodes of severe sepsis or septic shock occurred in study patients: 22 after study entry and 22 before study entry. Streptococcus pneumoniae was more frequent among sepsis episodes that occurred bef...Continue Reading

References

Jan 19, 2002·The Journal of Infection·N BisharatR Raz
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Feb 24, 2006·The American Journal of Medicine·Moe H KyawHarry Campbell
Feb 12, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anja M Werno, David R Murdoch
Oct 21, 2009·Annals of Internal Medicine·Reimar W ThomsenHenrik Toft Sørensen
Apr 9, 2011·Lancet·Antonio Di SabatinoGino Roberto Corazza
Oct 18, 2011·Journal of Infection and Public Health·Hélène Coignard-BiehlerOlivier Lortholary
Mar 8, 2012·The Journal of Infection·Albert Jan van HoekElizabeth Miller
Sep 25, 2014·Critical Care Medicine·Daniel Pilsgaard HenriksenAnnmarie Touborg Lassen
Dec 26, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christian TheilackerUNKNOWN Splenectomy, Pneumococcus, and Fulminant Infection SPLEEN OFF Study Group
Feb 19, 2017·The American Journal of Medicine·Aaron P MitchellDavid L Simel
Feb 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alicia ArnottAllen C Cheng
Aug 6, 2019·Surgery·Matthew C HernandezMartin D Zielinski

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