A Single Center Retrospective Evaluation of a Surgical Strategy to Combat Persistent Soft Tissue Wounds Utilizing Absorbable Antibiotic Beads

Advances in Wound Care
Joseph W GorvetzianChristopher P Demas

Abstract

Objective: To determine whether use of absorbable antibiotic-imbued beads in chronic soft tissue wounds presents a viable therapeutic modality. Approach: Retrospective analysis of all cases utilizing calcium sulfate antibiotic beads was conducted. Cases comprised complex wound and breast reconstruction performed by the senior author (C.P.D.) over 4 years at the University of New Mexico Hospital. All-cause need for reoperation and reoperation for infection in the 90 days following bead-assisted surgery were compared to traditional surgical intervention in the 90-day period preceding bead-assisted surgery. Paired-samples t-test and corrected Cohen's d were calculated for outcome significance and effect size. Results: A total of 60 patients underwent 84 bead-assisted surgeries. There was a significant decrease in rate of reoperation following bead surgery (M = 0.32) compared with prebead surgery (M = 2.2), p < 0.001. Rate of reoperation for infection significantly decreased from 1.7 before bead surgery to 0.05 following bead surgery, p < 0.001. Results remained significant when stratified by complex wound or breast reconstruction, p < 0.01. Cohen's d ranged from 1.25 to 2.13, with probability of superiority between 80% and 93%. In...Continue Reading

References

Oct 1, 1995·The Journal of Bone and Joint Surgery. American Volume·K L Garvin, A D Hanssen
Dec 1, 1996·Antimicrobial Agents and Chemotherapy·D A Wininger, R J Fass
Jun 5, 2001·The Journal of Antimicrobial Chemotherapy·D NeutH J Busscher
Nov 30, 2006·Advances in Skin & Wound Care·Carly KirshenR Gary Sibbald
May 23, 2007·Molecular Medicine·Harold BremMarjana Tomic-Canic
Dec 19, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Garth A JamesPhilip S Stewart
May 20, 2008·Acta Orthopaedica·Konstantinos AnagnostakosJens Kelm
Jul 16, 2008·Acta Orthopaedica·Javad ParviziMichael A Mont
Dec 23, 2008·International Journal of Antimicrobial Agents·Kyriaki KanellakopoulouEvangelos J Giamarellos-Bourboulis
Jan 6, 2009·The Journal of Bone and Joint Surgery. American Volume·Esa JämsenTeemu Moilanen
Jun 23, 2010·Seminars in Plastic Surgery·Jaspaul S GogiaAmir A Jamali
Aug 28, 2010·Clinics in Dermatology·Abdul R Siddiqui, Jack M Bernstein
Oct 13, 2010·Archives of Orthopaedic and Trauma Surgery·Peter WahlThierry Buclin
Feb 3, 2012·The Journal of Bone and Joint Surgery. American Volume·Christopher J WahlAmy M Cizik
Jan 1, 2014·Plastic and Reconstructive Surgery·James D KretlowShayan A Izaddoost
Jun 1, 2012·Advances in Wound Care·Christopher Attinger, Randy Wolcott
Apr 29, 2014·The Journal of Pathology·Sashwati RoyChandan K Sen
Jan 22, 2017·Advances in Therapy·George Han, Roger Ceilley
Feb 17, 2017·The American Surgeon·Terris L WhiteChristopher P Demas
Apr 27, 2017·Plastic and Reconstructive Surgery·Jenny C BarkerGayle M Gordillo
Jun 28, 2017·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Rami D SherifMarco A Harmaty

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