A Single-Centre, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Investigate the Efficacy and Safety of Minoxidil Topical Foam in Frontotemporal and Vertex Androgenetic Alopecia in Men

Skin Pharmacology and Physiology
Kathrin HillmannUlrike Blume-Peytavi

Abstract

5% minoxidil formulations twice daily are effective in treating vertex male androgenetic alopecia (AGA); however, efficacy and safety data in frontotemporal regions are lacking. To assess the efficacy of 5% minoxidil topical foam (5% MTF) in the frontotemporal region of male AGA patients after 24 weeks of treatment compared to placebo treatment and to the vertex region. Seventy males with moderate AGA applied 5% MTF or placebo foam (plaTF) twice daily for 24 weeks in frontotemporal and vertex regions. Target area non-vellus hair count (TAHC) was the primary end point. Frontotemporal and vertex TAHC and target area cumulative non-vellus hair width (TAHW) showed similar responses to 5% MTF with significant increases up to week 16 compared to baseline (p < 0.001). After 24 weeks of treatment, frontotemporal TAHW increased significantly in the 5% MTF group compared to the plaTF group (p = 0.017), while TAHC showed a similar non-significant increase from baseline in both regions. At 24 weeks, 5% MTF users rated a significant improvement in scalp coverage for the frontotemporal (p = 0.016) and vertex areas (p = 0.027). 5% MTF twice a day promotes hair density and width in both frontotemporal and vertex regions in men with moderate st...Continue Reading

Citations

Sep 22, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·V KantiU Blume-Peytavi
Sep 13, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Aditya K Gupta, Kelly A Foley
Dec 30, 2017·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Sean W Delaney, Paul Zhang
Jun 5, 2018·The Journal of Dermatology·Motomu ManabeUNKNOWN Drafting Committee for the Guidelines for the Diagnosis and Treatment of Male- and Female-Pattern Hair Loss
Feb 20, 2018·Skin Appendage Disorders·Jessica CervantesJoaquin J Jimenez
May 26, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·A K GuptaV Piguet
Jun 24, 2021·The Journal of Dermatological Treatment·A K GuptaM A Bamimore

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