A single chimpanzee-human neutralizing monoclonal antibody provides post-exposure protection against type 1 and type 2 polioviruses

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Diana KouiavskaiaKonstantin Chumakov

Abstract

Development of anti-poliovirus therapies to complement vaccination is an urgent priority. A number of antiviral drugs are in development. Recently we have developed human monoclonal antibodies that could be used for treatment of chronically infected individuals and emergency response to potential reappearance of polioviruses after eradication. The aim of this study was to characterize neutralizing activity of anti-poliovirus monoclonal antibody A12 against wild type, vaccine-derived, and drug-resistant poliovirus strains, evaluate in vivo pre- and post-exposure protective properties of the antibody against polioviruses of serotypes 1 and 2, and to determine whether it interferes with response to immunization with poliovirus vaccine. Immunogenicity studies were performed in CD1 mice. Poliovirus neutralizing titers were determined in poliovirus microneutralization assay. Poliovirus immunization-challenge experiments were performed in poliovirus-susceptible TgPVR21 mice. We show that monoclonal antibody A12 effectively neutralizes in vitro a broad range of type 1 and type 2 wild and vaccine-derived polioviruses, provides effective pre- and post-exposure protection of TgPVR21 mice from challenge with a lethal dose of poliovirus. Tr...Continue Reading

References

Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S KoikeA Nomoto
Jan 1, 1987·Annual Review of Microbiology·J W Almond
Mar 9, 1996·Lancet·H F Hull, J W Lee
May 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Julie K Pfeiffer, Karla Kirkegaard
Sep 13, 2005·Annual Review of Microbiology·Olen M KewMark A Pallansch
Jun 3, 2008·Antiviral Research·Marc S CollettJohn F Modlin
Aug 15, 2012·Antimicrobial Agents and Chemotherapy·Hong-Mei LiuM Steven Oberste
May 16, 2014·Antiviral Research·Rama Devudu PuligeddaKonstantin Chumakov

❮ Previous
Next ❯

Citations

May 6, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Andreina BajAntonio Toniolo
Jul 12, 2017·Scientific Reports·Angelo GenoniAntonio Toniolo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.