A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice

American Journal of Physiology. Endocrinology and Metabolism
Eline N KuipersMariëtte R Boon

Abstract

Brown adipose tissue (BAT) catabolizes glucose and fatty acids to produce heat and thereby contributes to energy expenditure. Long-term high-fat diet (HFD) feeding results in so-called 'whitening' of BAT characterized by increased lipid deposition, mitochondrial dysfunction, and reduced fat oxidation. The aim of the current study was to unravel the rate and related mechanisms by which HFD induces BAT whitening and insulin resistance. Wild-type mice were fed a HFD for 0, 1, 3, or 7 days. Within 1 day of HFD, BAT weight and lipid content were increased. HFD also immediately reduced insulin-stimulated glucose uptake by BAT, indicating rapid induction of insulin resistance. This was accompanied by a tendency toward a reduced uptake of triglyceride-derived fatty acids by BAT. Mitochondrial mass and Ucp1 expression were unaltered, whereas after 3 days of HFD, markers of mitochondrial dynamics suggested induction of a more fused mitochondrial network. Additionally, HFD also increased macrophage markers in BAT after 3 days of HFD. Counterintuitively, the switch to HFD was accompanied by an acute rise in core body temperature. We showed that a single day of HFD feeding is sufficient to induce the first signs of whitening and insulin res...Continue Reading

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Citations

Oct 16, 2020·The British Journal of Nutrition·Mariana Rosas FernándezKelse T Albuquerque
Nov 5, 2020·Molecular Psychiatry·Wolfgang MarxFelice N Jacka
Oct 6, 2020·Biochemical and Biophysical Research Communications·Rehab AlshargabiFusanori Nishimura

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Methods Mentioned

BETA
ELISA
GTPase
PCR
Protein Assay

Software Mentioned

LinRegPCR
Bio
SPSS
AcqKnowledge
LightCycler
ImageJ
Rad Image Laboratory

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