A single dose combination study with the experimental antimalarials artefenomel and DSM265 to determine safety and antimalarial activity against blood-stage Plasmodium falciparum  in healthy volunteers

doi:10.1128/aac.01371-19

A single dose combination study with the experimental antimalarials artefenomel and DSM265 to determine safety and antimalarial activity against blood-stage Plasmodium falciparum in healthy volunteers

Antimicrobial Agents and Chemotherapy

Nov 4, 2019

James S. McCarthyJörg J Möhrle

PMID: 31685476

DOI: 10.1128/aac.01371-19

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Abstract

Artefenomel and DSM265 are two new compounds that have been shown to be well tolerated and effective when administered as monotherapy malaria treatment. This study aimed to determine the safety, pharmacokinetics and pharmacodynamics of artefenomel and DSM265 administered in combination ...read more

Mentioned in this Paper

Antimalarials

Erythrocytes

Human Volunteers

Kidney Failure, Chronic

Malaria

Malaria, Falciparum

Parasites

Drug Kinetics

Plasma

Plasmodium falciparum

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A single dose combination study with the experimental antimalarials artefenomel and DSM265 to determine safety and antimalarial activity against blood-stage Plasmodium falciparum in healthy volunteers

Abstract