A single dose of a non-steroidal anti-inflammatory drug (NSAID) prevents severe pain after ureteric stent removal: a prospective, randomised, double-blind, placebo-controlled trial

BJU International
Nicholas N TadrosMichael J Conlin

Abstract

To determine the incidence of severe pain after ureteric stent removal. To evaluate the efficacy of a single dose of a non-steroidal anti-inflammatory drug (NSAID) in preventing this complication. A prospective, randomised, double-blind, placebo-controlled trial was performed at our institution. Adults with an indwelling ureteric stent after ureteroscopy were randomised to receive either a single dose of placebo or an NSAID (rofecoxib 50 mg) before ureteric stent removal. Pain was measured using a visual analogue scale (VAS) just before and 24 h after stent removal Pain medication use after ureteric stent removal was measured using morphine equivalents. In all, 22 patients were enrolled and randomised into the study before ending the study after interim analysis showed significant decrease in pain level in the NSAID group. The most common indication for ureteroscopy was urolithiasis (14 patients). The proportion of patients with severe pain (VAS score of ≥7) during the 24 h after ureteric stent removal was six of 11 (55%) in the placebo group and it was zero of 10 in the NSAID group (P < 0.01). There were no complications related to the use of rofecoxib. We found a 55% incidence of severe pain after ureteric stent removal. A si...Continue Reading

References

Jan 1, 1988·The Journal of Urology·S G Pollard, R Macfarlane
Nov 8, 2001·Journal of Endourology·A RaneR Tiptaft
Feb 11, 2003·The Journal of Urology·H B JoshiMichael J Barry
Feb 17, 2005·The New England Journal of Medicine·Robert S BresalierUNKNOWN Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators
Mar 8, 2008·Journal of Endourology·C Charles WenStephen Y Nakada
Nov 18, 2008·The Journal of Urology·Richard BeddingfieldManoj Monga
Aug 21, 2010·The Journal of Urology·Athanasios DellisFrancis X Keeley

❮ Previous
Next ❯

Citations

Aug 20, 2014·Journal of Endourology·Nithin TheckumparampilZeph Okeke
Jul 31, 2014·World Journal of Urology·Richard H ShinGlenn M Preminger
Jul 16, 2014·Journal of Endourology·Jeffrey C Loh-DoyleMike M Nguyen
Jan 18, 2013·BJU International·Matthew Bultitude
Feb 2, 2018·Scandinavian Journal of Urology·Dan Holmlund
Dec 3, 2015·Current Opinion in Urology·Ben H Chew, Christian Seitz
Nov 29, 2013·BJU International·Prokar Dasgupta
Apr 30, 2016·Journal of Endourology·Christopher KoprowskiSammy E Elsamra
Apr 13, 2013·BJU International·Michael J Conlin
Oct 17, 2017·BJU International·Matthew Bultitude
Jun 13, 2018·Current Urology Reports·Katherine M FischerPhillip Mucksavage
Sep 25, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Gaurav Mohan Sali, Hrishikesh B Joshi
Feb 20, 2016·Experimental and Therapeutic Medicine·Peng ZhangGang Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.