A single dose of ceftriaxone administered 30 minutes before percutaneous endoscopic gastrostomy significantly reduces local and systemic infective complications

The American Journal of Gastroenterology
A J DormannH Huchzermeyer

Abstract

The aim of this study was to determine the efficacy of antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG). An open prospective, randomised, multicenter study was conducted in 141 patients; 72 received ceftriaxone 1 g i.v. 30 min preintervention, and 69 received no study medication. A standardized protocol was followed for PEG preparation, insertion, and aftercare; all patients received a 15-Fr gastrostomy tube. Follow-up of local and systemic infection and clinical course was continued to postintervention day 10. An aggregate erythema and exudation score >3 or the presence of pus was taken as indicative of peristomal infection. The pharmacoeconomics of antibiotic use were also examined. In no-prophylaxis patients, wound infection rates were 25% on day 4 and 26.4% on day 10, versus 10.1% (p = 0.03) and 14.5% (p = 0.10), respectively, in prophylaxis patients. Results were disproportionally better in tumor patients: systemic infection rates were 16.7% versus 5.8% in no-prophylaxis versus prophylaxis patients (p = 0.045), and overall infection rates 38.9% versus 17.4%, respectively (p = 0.046). Pneumonia was more frequent in patients with underlying neurological disease. Antibiotic costs were the same in both group...Continue Reading

References

Mar 1, 1988·Journal of Speech and Hearing Research·R M Cox, J N Moore
Mar 1, 1985·La Revue de médecine interne·T Bergan
Nov 1, 1982·Antimicrobial Agents and Chemotherapy·A A PollockJ J Rahal
Dec 30, 1982·The New England Journal of Medicine·M ShapiroB F Polk
Dec 1, 1980·Journal of Pediatric Surgery·M W GaudererR J Izant
Sep 1, 1996·Journal of Gastroenterology and Hepatology·M A Chowdhury, R Batey
May 21, 1998·Endoscopy·J D Mellinger, J L Ponsky

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Citations

Jun 1, 2005·Seminars in Interventional Radiology·Ali Zarrinpar, Robert K Kerlan
Nov 1, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kurt B Nolte, Steven S Yoon
Nov 1, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ricardo DurlachMarta Costa
Nov 1, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Stephen J Wilson, Daniel J Sexton
Nov 1, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Matthieu EveillardFrançois Eb
Nov 1, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·David M PoetkerPhillip A Wackym
Nov 1, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Michael Wilson
Nov 1, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Gilbert Greub, Didier Raoult
Feb 4, 2006·The American Journal of Gastroenterology·Akira HoriuchiNaoki Tanaka
Feb 24, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Kayal VizhiRama P Venu
Jun 15, 2006·The American Journal of Gastroenterology·Arno J DormannPeter Malfertheiner
Apr 4, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Manpreet S MundiRyan T Hurt
Aug 8, 2006·Current Opinion in Gastroenterology·Kathryn R Byrne, John C Fang
May 11, 2010·Journal of Pediatric Gastroenterology and Nutrition·Christian BraeggerJohannes van Goudoever
Jun 16, 2005·Journal of Gastroenterology and Hepatology·Ahmet ErdilKemal Dagalp
May 31, 2013·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·I WallstabeA Weimann
Jun 5, 2014·Scandinavian Journal of Gastroenterology·Andrea S SchneiderAhmed A Negm
Apr 5, 2003·Wiener klinische Wochenschrift·Gerhard AschlPeter Knoflach
Jan 19, 2006·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Elizabeth GoldbergChris Liacouras
Jan 7, 2016·European Journal of Gastroenterology & Hepatology·Denise StrijbosLennard P L Gilissen
Mar 4, 2011·Journal of the American Geriatrics Society·Keith S KayeKenneth E Schmader
Dec 12, 2001·Alimentary Pharmacology & Therapeutics·M HullC Settle
Apr 9, 2002·Journal of Chemotherapy·S Colizza, S Rossi

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