A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Charles D Nichols, Elaine Sanders-Bush

Abstract

Hallucinogenic drugs such as lysergic acid diethylamide (LSD) have profound effects on humans including hallucinations and detachment from reality. These remarkable behavioral effects have many similarities to the debilitating symptoms of neuropsychiatric disorders such as schizophrenia. The effects of hallucinogens are thought to be mediated by serotonin receptor activation; however, how these drugs elicit the unusual behavioral effects remains largely a mystery, despite much research. We have undertaken the first comprehensive analysis of gene expression influenced by acute LSD administration in the mammalian brain. These studies represent a novel approach to elucidate the mechanism of action of this class of drugs. We have identified a number of genes that are predicted to be involved in the processes of synaptic plasticity, glutamatergic signaling and cytoskeletal architecture. Understanding these molecular events will lead to new insights into the etiology of disorders whose behavioral symptoms resemble the temporary effects of hallucinogenic drugs, and also may ultimately result in new therapies.

Citations

Jun 15, 2011·Journal of Computational Neuroscience·Zachary P Kilpatrick, G Bard Ermentrout
Feb 6, 2004·Pharmacology & Therapeutics·David E Nichols
Mar 26, 2003·Brain Research. Molecular Brain Research·Charles D NicholsElaine Sanders-Bush
Nov 19, 2002·Neuroscience·C D NicholsE Sanders-Bush
Mar 1, 2003·Drug and Alcohol Dependence·John H Halpern, Harrison G Pope
Mar 18, 2003·Brain Research. Gene Expression Patterns·Valeria Gonzalez-Nicolini, Jacqueline F McGinty
Sep 15, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen K SzumlinskiPeter W Kalivas
Jan 28, 2005·The European Journal of Neuroscience·Christine C StichelHermann Lübbert
Jul 14, 2005·Genes, Brain, and Behavior·K K SzumlinskiP W Kalivas
Mar 19, 2011·Pharmacological Reviews·Udai Bhan Pandey, Charles D Nichols
Jun 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Atheir I AbbasBryan L Roth
Apr 8, 2014·Neuropharmacology·David A MartinCharles D Nichols
Feb 5, 2016·Pharmacological Reviews·David E Nichols
Dec 2, 2008·CNS Neuroscience & Therapeutics·Torsten PassieAnnelie Hintzen
Sep 4, 2007·Biochemical Pharmacology·Karen K SzumlinskiKevin D Lominac
Jun 14, 2005·Brain Research. Molecular Brain Research·Eisuke KoyaAugust B Smit
Jun 17, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ruud P W LitjensRemco H S Westerink
Aug 8, 2014·Journal of Neurochemistry·Elizabeth A HellerMichelle S Mazei-Robison
Mar 1, 2011·Neuropharmacology·Danuta Marona-LewickaDavid E Nichols
Dec 2, 2008·Expert Opinion on Pharmacotherapy·Atheir Abbas, Bryan L Roth
Jan 30, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andrea de BartolomeisFelice Iasevoli
Dec 2, 2011·Drug and Alcohol Dependence·Matthew W JohnsonRoland R Griffiths
Mar 13, 2012·The International Journal of Neuropsychopharmacology·Madhurima BenekareddyVidita A Vaidya
May 7, 2016·Human Brain Mapping·A V LebedevR L Carhart-Harris
Jul 6, 2010·Journal of Psychiatric Research·Ilja SpellmannMichael Riedel
Dec 18, 2003·Physiological Genomics·Sergio Kaiser, Laura K Nisenbaum
Aug 2, 2014·Therapeutic Advances in Psychopharmacology·David BaumeisterDerek Tracy
Jul 16, 2019·Journal of Psychopharmacology·Kim Pc KuypersDavid Nutt
Sep 26, 2015·Pharmacological Reviews·Esa R KorpiGavin S Dawe
May 7, 2020·Regional Anesthesia and Pain Medicine·Joel P CastellanosTimothy Furnish
Sep 10, 2020·Scientific Reports·Marie A DoyleMichelle S Mazei-Robison
Dec 5, 2019·Frontiers in Pharmacology·Richard J ZeifmanDraulio B Araujo
Mar 17, 2018·Frontiers in Pharmacology·Emmanuelle A D SchindlerDeepak C D'Souza
Nov 5, 2020·Journal of Psychopharmacology·Oskar Hougaard JefsenHeidi Kaastrup Müller
Dec 1, 2020·The International Journal of Neuropsychopharmacology·Bashkim KadriuCarlos A Zarate

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