PMID: 11322709Apr 27, 2001Paper

A single dose of melatonin prevents the phase delay associated with a delayed weekend sleep pattern

Sleep
C M YangJ Birnbaum

Abstract

This study was designed to test the hypotheses that a delayed weekend sleep pattern may lead to a phase delay of the endogenous circadian rhythm, and that melatonin administration can counteract the phase delay and prevent the sleep and functional impairments associated with this sleep pattern. A within-subject, counterbalanced design was used in which each subject participated in both placebo and melatonin conditions. Subjects' sleep-wake schedules were delayed by two hours on Friday and Saturday to simulate the delayed weekend sleep pattern. Six mg of melatonin or a placebo pill was administered double blind on Sunday late afternoon. N/A. Ten healthy volunteers (mean age = 22.1 years old). Salivary dim-light melatonin onset (DLMO) was measured on Friday and Monday nights. Subject's sleep was recorded with polysomnography on Sunday night and their levels of sleepiness, cognitive functioning and mood were assessed on Sunday night and Monday morning. Results show that the delayed weekend sleep pattern caused a 31.6 min delay of the endogenous melatonin rhythm. Melatonin administration counteracted the phase delay of endogenous melatonin onset. On Sunday, melatonin administration increased the sleepiness throughout the evening an...Continue Reading

Citations

Feb 23, 2007·Behavioral Sleep Medicine·Leon C Lack, Helen R Wright
Dec 8, 2010·Journal of Biological Rhythms·Helen J Burgess
Aug 28, 2010·Chronobiology International·Stephanie J Crowley, Mary A Carskadon
Nov 10, 2009·Journal of Occupational Rehabilitation·Lia R A BittencourtSergio Tufik
Dec 18, 2009·European Archives of Psychiatry and Clinical Neuroscience·Shadab Ataur RahmanColin Michael Shapiro
Jun 12, 2014·Photochemistry and Photobiology·Helen J Burgess, Thomas A Molina
Feb 24, 2017·Drugs·Jonathan S Emens, Charmane I Eastman
Jul 11, 2018·American Journal of Physical Anthropology·Gandhi YetishMichael Gurven
Jun 12, 2019·International Archives of Occupational and Environmental Health·Tine Almenning FlaaSiri Waage
Aug 17, 2002·Chronobiology International·Stacia K Martin, Charmane I Eastman
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Jun 29, 2012·Journal of Physiological Anthropology·Jim WaterhouseTakeshi Morita
May 16, 2014·Chronobiology International·Shingo KitamuraKazuo Mishima
Oct 7, 2014·Chronobiology International·Adam C StowieJ David Glass
Feb 21, 2021·Journal of Pineal Research·Giulia ZerbiniMartha Merrow
Sep 2, 2021·International Journal of Bipolar Disorders·Parisa VidafarHelen J Burgess

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